| New neolignan from seed of Myristica fragrans | |
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MedLine Citation:
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PMID: 18533495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the chemical constituents in the nutmeg (seed of Myristica fragrans). METHOD: The chemical constituents were isolated by various column chromatographic methods and structurally elucidated by IR, NMR and MS evidences. RESULT: Fifteen compounds were obtained and identified as myristicin (1), methyleugenol (2), safrole (3), 2, 3-dihydro-7-methoxy-2(3, 4-methylenedioxyphenyl)-3-methyl-5-(E) -propenyl-benzofuran (4), dehydrodiisoeugenol (5), 2, 3-dihydro-7-methoxy-2-(3-methoxy-4, 5-methylenedioxyphenyl) -3-methyl-5-(E)-propenyl-benzofuran (6), erythro-2-(4-allyl-2, 6-dimethoxyphenoxy)-1-(3, 4-dimetho- xyphenyl) propane (7), erythro-2-(4-allyl-2, 6-dimethoxyphenoxy)-1-(3, 4, 5-trimethoxyphenyl) propane (8), erythro-2-(4-allyl-2, 6-dimethoxyphenoxy)-1-(3, 4-dimethoxyphenyl) propan-1-ol acetate (9), erythro-2-(4-allyl-2, 6-dimethoxyphenoxy)-1-(3, 4-dimethoxyphenyl) propan-1-ol (10), erythro-2-(4-allyl-2, 6-dimethoxyphenoxy)-1-(3, 4, 5-trimethoxyphenyl) propan-1-ol (11), 5-methoxy-dehydrodiisoeugenol (12), erythro-2-(4-allyl-2, 6-dimethoxyphenoxy)-1-(4-hydroxy-3-methoxyphenyl)-propan-1-ol (13), guaiacin (14) and threo-2-(4-allyl-2, 6-dimethoxyphenoxy)-1-(3-methoxy-5-hydroxy-phenyl) propan-1-ol (15). CONCLUSION: Compound 15 is a new compound and named myrisisolignan. Compound 7 is isolated from the genus Myristica for the first time. |
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Authors:
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Xiu-Wei Yang; Xin Huang; Mamat Ahmat |
Publication Detail:
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Type: English Abstract; Journal Article |
Journal Detail:
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Title: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica Volume: 33 ISSN: 1001-5302 ISO Abbreviation: Zhongguo Zhong Yao Za Zhi Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-06-06 Completed Date: 2009-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913656 Medline TA: Zhongguo Zhong Yao Za Zhi Country: China |
Other Details:
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Languages: chi Pagination: 397-402 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China. xwyang@bjmu.edu.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Benzofurans
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chemistry,
isolation & purification Benzyl Compounds / chemistry, isolation & purification Dioxolanes / chemistry, isolation & purification Eugenol / analogs & derivatives, chemistry, isolation & purification Lignans / chemistry*, isolation & purification Magnetic Resonance Spectroscopy Molecular Structure Myristica fragrans / chemistry* Pyrogallol / analogs & derivatives, chemistry, isolation & purification Safrole / chemistry, isolation & purification Seeds / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Benzofurans; 0/Benzyl Compounds; 0/Dioxolanes; 0/Lignans; 0/dehydrodiisoeugenol; 271-89-6/benzofuran; 607-91-0/myristicin; 87-66-1/Pyrogallol; 93-15-2/methyleugenol; 94-59-7/Safrole; 97-53-0/Eugenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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