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New multifunctional surfactants from natural phenolic acids.
MedLine Citation:
PMID:  22142033     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We synthesized several new multifunctional molecules derived from natural sources such as amino acids and hydroxycinnamic acids. They exhibit various activities such as emulsifying, UV-protecting and radical scavenging, thereby conforming to the latest requirements for cosmetic ingredients. The synthesis comprises only a few steps: i) the amino acid, whose acid group(s) are protected by esterification, is coupled with ferulic or caffeic acid; ii) the p-hydroxyl group of the cinnamic derivative reacts with dodecyl bromide in the presence of potassium carbonate; the resulting compounds are highly lipophilic and tested as water/oil (w/o) emulsifiers; iii) these molecules, by de-protonating the acid groups of the amino acids, with successive salification, are more hydrophilic, with stronger o/w emulsifying properties. The new multifunctional surfactants might prove useful for the treatment of multiple skin conditions, including loss of cellular antioxidants, damage from free radicals, damage from UV, and others.
Authors:
Marisanna Centini; Maria Sole Rossato; Alessandro Sega; Anna Buonocore; Sara Stefanoni; Cecilia Anselmi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-5
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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