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New model of reperfused stroke by occlusion of the anterior cerebral artery in baboons.
MedLine Citation:
PMID:  20886244     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: The understanding of stroke has been greatly enhanced by studies employing nonhuman primate models of focal ischemia. However, devastating neurological disability in previously described stroke models has led to ethical concerns and difficulty achieving prolonged survival for the evaluation of long-term outcome. We determined if reversible occlusion of the anterior cerebral artery in baboons would produce a small infarct with minimal neurological impairment.
METHODS: In six baboons, anesthetized with isoflurane, Guglielmi coils were placed by endovascular technique in the anterior cerebral artery. In two baboons coils were placed for 3 h at the proximal A2 segment. In four baboons coils were placed at the junction of the A2 and A3 segments of the anterior cerebral artery for 1.5 h (n = 2) or 3 h (n = 2). The coils were removed and reperfusion confirmed by angiography. Thereafter, the animals were awakened from anesthesia and brain MRI studies were performed at 1 week.
RESULTS: Baboons awakened with minimal neurological impairment. Animals subject to occlusion at the proximal A2 segment and animals subject to 1.5 h of occlusion at the junction of A2 and A3 had no infarct. Animals with 3-h occlusion at the junction of A2 and A3 showed infarcts of 3.5% and 2.8% of cerebral hemispheres.
CONCLUSIONS: This study indicates that reversible anterior cerebral artery occlusion may provide a new humane animal model for small stroke and limited neurological deficit.
Authors:
Arthur E Schwartz; John Pile-Spellman
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Publication Detail:
Type:  Journal Article     Date:  2010-10-02
Journal Detail:
Title:  Acta neurochirurgica     Volume:  153     ISSN:  0942-0940     ISO Abbreviation:  Acta Neurochir (Wien)     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151000     Medline TA:  Acta Neurochir (Wien)     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  327-31     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, The Mount Sinai School of Medicine, 1 Gustave Levy Place, P.O. Box 1010, New York, NY, 10029, USA, arthur.schwartz@mountsinai.org.
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