Document Detail

New model of progressive non-insulin-dependent diabetes mellitus in mice induced by streptozotocin.
MedLine Citation:
PMID:  10513628     Owner:  NLM     Status:  MEDLINE    
This study was designed to clarify the relationship between streptozotocin (STZ) dosage (100, 150 and 200 mg/kg i.p.) and the resulting diabetogenic response in mice (8-week-old male ICR). In this experiment, we found that a single i.p. injection of 100 mg/kg STZ is able to induce progressive diabetes mellitus, in which non-fasting serum glucose levels begin to rise from 3 weeks and continue to rise throughout the experimental period until 9 weeks. The non-fasting serum insulin levels of 100 mg/kg STZ-treated mice were normal during the experimental period. In addition, the population of insulin-immunoreactive cells (beta cells) in the islets of pancreata was slightly less than in normal mice at 9 weeks. In 200 mg/kg STZ-treated mice, on the other hand, the insulin levels were below measurable values and insulin-immunoreactive cells were not observed. It is concluded from these results that the progressive diabetic mouse model induced by a single i.p. injection of 100 mg/kg STZ, unlike 200 mg/kg STZ-induced diabetes which is insulin-dependent, is non-insulin-dependent.
M Ito; Y Kondo; A Nakatani; A Naruse
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  22     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-11-24     Completed Date:  1999-11-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  988-9     Citation Subset:  IM    
Department of Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
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MeSH Terms
Age Factors
Anti-Bacterial Agents / toxicity
Blood Glucose / metabolism
Diabetes Mellitus, Experimental*
Diabetes Mellitus, Type 2 / chemically induced*,  metabolism
Dose-Response Relationship, Drug
Mice, Inbred ICR
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Blood Glucose; 18883-66-4/Streptozocin

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