Document Detail


New model of progressive non-insulin-dependent diabetes mellitus in mice induced by streptozotocin.
MedLine Citation:
PMID:  10513628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was designed to clarify the relationship between streptozotocin (STZ) dosage (100, 150 and 200 mg/kg i.p.) and the resulting diabetogenic response in mice (8-week-old male ICR). In this experiment, we found that a single i.p. injection of 100 mg/kg STZ is able to induce progressive diabetes mellitus, in which non-fasting serum glucose levels begin to rise from 3 weeks and continue to rise throughout the experimental period until 9 weeks. The non-fasting serum insulin levels of 100 mg/kg STZ-treated mice were normal during the experimental period. In addition, the population of insulin-immunoreactive cells (beta cells) in the islets of pancreata was slightly less than in normal mice at 9 weeks. In 200 mg/kg STZ-treated mice, on the other hand, the insulin levels were below measurable values and insulin-immunoreactive cells were not observed. It is concluded from these results that the progressive diabetic mouse model induced by a single i.p. injection of 100 mg/kg STZ, unlike 200 mg/kg STZ-induced diabetes which is insulin-dependent, is non-insulin-dependent.
Authors:
M Ito; Y Kondo; A Nakatani; A Naruse
Related Documents :
9458968 - Time course of changes in heart rate and blood pressure variability in streptozotocin-i...
12079878 - Effect of brx-220 against peripheral neuropathy and insulin resistance in diabetic rat ...
16624628 - Specific impairment of endothelium-derived hyperpolarizing factor-type relaxation in me...
16025228 - Taurine may prevent diabetic rats from developing cardiomyopathy also by downregulating...
15621288 - A new orally active antidiabetic vanadyl complex--bis(alpha-furancarboxylato)oxovanadiu...
16150198 - The state of insulin resistance in patients with nonalcoholic fatty liver and the inter...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  22     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-11-24     Completed Date:  1999-11-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  988-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Anti-Bacterial Agents / toxicity
Blood Glucose / metabolism
Diabetes Mellitus, Experimental*
Diabetes Mellitus, Type 2 / chemically induced*,  metabolism
Dose-Response Relationship, Drug
Male
Mice
Mice, Inbred ICR
Streptozocin*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Blood Glucose; 18883-66-4/Streptozocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Relaxant effects of pyranocoumarin compounds isolated from a Chinese medical plant, Bai-Hua Qian-Hu,...
Next Document:  Antimicrobial activity and metalloprotease inhibition of hinokitiol-related compounds, the constitue...