Document Detail

New modalities of brain stimulation for stroke rehabilitation.
MedLine Citation:
PMID:  23192336     Owner:  NLM     Status:  MEDLINE    
Stroke is a leading cause of disability, and the number of stroke survivors continues to rise. Traditional neurorehabilitation strategies aimed at restoring function to weakened limbs provide only modest benefit. New brain stimulation techniques designed to augment traditional neurorehabilitation hold promise for reducing the burden of stroke-related disability. Investigators discovered that repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS), and epidural cortical stimulation (ECS) can enhance neural plasticity in the motor cortex post-stroke. Improved outcomes may be obtained with activity-dependent stimulation, in which brain stimulation is contingent on neural or muscular activity during normal behavior. We review the evidence for improved motor function in stroke patients treated with rTMS, tDCS, and ECS and discuss the mediating physiological mechanisms. We compare these techniques to activity-dependent stimulation, discuss the advantages of this newer strategy for stroke rehabilitation, and suggest future applications for activity-dependent brain stimulation.
M A Edwardson; T H Lucas; J R Carey; E E Fetz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-11-29
Journal Detail:
Title:  Experimental brain research     Volume:  224     ISSN:  1432-1106     ISO Abbreviation:  Exp Brain Res     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-08-07     Revised Date:  2014-05-12    
Medline Journal Info:
Nlm Unique ID:  0043312     Medline TA:  Exp Brain Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  335-58     Citation Subset:  IM    
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MeSH Terms
Brain / physiopathology*
Electric Stimulation Therapy / methods*
Functional Laterality / physiology
Recovery of Function / physiology
Stroke / physiopathology,  rehabilitation*
Transcranial Magnetic Stimulation / methods*
Grant Support

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