| New methods in laboratory diagnostics of dilated cardiomyopathy. | |
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MedLine Citation:
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PMID: 18698552 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dilated cardiomyopathy (DCM) is a multifactorial heart disease in which there is enlargement and systolic dysfunction of one or both ventricles. The exhaustion of compensatory mechanisms leads to symptoms of congestive heart failure, which is a significant problem in contemporary cardiology. DCM is still diagnosed using clinical assessment; echocardiography is necessary, and in some clinical situations we need hemodynamic assessment in order to identify the etiology and progression of heart disease. These tests are necessary for choice of treatment and qualification for heart transplant. Investigators are looking for new, valuable, additional parameters which could be of use in screening and heart disease progression assessment, and which may be helpful in the management and risk stratification of patients with DCM. These monitoring and prognostic tools in patients with chronic heart failure can be biomarkers, such as natriuretic peptides: BNP and NT-proBNP, cardiac troponins or inflammatory cytokines and their receptors. Moreover, there are ongoing research projects concerning persistently elevated uric acid, Ca-125 and osteopontin concentrations for the identification of patients with DCM, as well as adverse prognoses. |
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Authors:
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Agata Bielecka-Dabrowa; Magdalena Wierzbicka; Marek Dabrowa; Aleksander Goch |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cardiology journal Volume: 15 ISSN: 1897-5593 ISO Abbreviation: - Publication Date: 2008 |
Date Detail:
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Created Date: 2008-08-13 Completed Date: 2008-11-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101392712 Medline TA: Cardiol J Country: Poland |
Other Details:
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Languages: eng Pagination: 388-95 Citation Subset: IM |
Affiliation:
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1st Department of Cardiology and Cardiosurgery, Medical University, Łódź, Poland. agatbiel7@poczta.onet.pl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood* Cardiomyopathy, Dilated / blood, diagnosis* Cytokines / metabolism* Disease Progression Echocardiography, Doppler Female Humans Male Monitoring, Physiologic / methods Natriuretic Peptide, Brain / analysis, blood Peptide Fragments / analysis Risk Assessment Sensitivity and Specificity Severity of Illness Index Troponin T / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cytokines; 0/Peptide Fragments; 0/Troponin T; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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