Document Detail

New method of microwave thermokeratoplasty to correct myopia in 33 eyes: One-year results.
MedLine Citation:
PMID:  23332252     Owner:  NLM     Status:  In-Data-Review    
PURPOSE: To assess the safety, predictability, and stability of a new microwave thermokeratoplasty procedure to correct myopia.
SETTING: Cornea and refractive surgery subspecialty.
DESIGN: Prospective clinical trial.
METHOD: Thermokeratoplasty was performed in myopic eyes at a single center in Turkey from June 2009 to June 2010. The attempted corrections ranged from -1.25 to -5.75 diopters (D). The main outcome measures were changes in logMAR uncorrected distance visual acuity (UDVA) and in keratometry (K) values.
RESULTS: The procedure was performed in 33 eyes (patients aged 20 to 45 years). The mean preoperative logMAR UDVA (0.76 ± 0.24 [SD]) significantly improved to 0.19 ± 0.20 at 1 month, postoperatively. By 3 months, the mean UDVA had markedly regressed to 0.59 ± 0.29; however, the residual improvement remained statistically significant. At 12 months, the mean logMAR UDVA was 0.72 ± 0.26. The mean K values were 43.9 ± 1.36 D preoperatively, 41.25 ± 2.63 D at 1 month, 43.4 ± 1.69 D at 3 months, and 44.1 ± 1.09 D at 12 months. The mean endothelial cell density was 2836 ± 342 cells/mm(2) preoperatively and were statistically unchanged 12 months postoperatively (2732 ± 353 cell/mm(2)). No patient lost lines of corrected distance visual acuity by 12 months postoperatively.
CONCLUSIONS: The new thermokeratoplasty procedure produced the desired reduction in myopia and improvement in postoperative UDVA 1 month postoperatively without significant side effects. However, early and complete regression shows the need for further development of this technique.
FINANCIAL DISCLOSURE: Drs. Yilmaz and Marshall are paid consultants to Avedro, Inc., and Dr. Muller is president and CEO of Avedro, Inc. No other author has a financial or proprietary interest in any material or method mentioned.
Ugur Celik; Nese Alagoz; Yusuf Yildirim; Alper Agca; John Marshall; David Muller; Ahmet Demirok; Omer Faruk Yilmaz
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cataract and refractive surgery     Volume:  39     ISSN:  1873-4502     ISO Abbreviation:  J Cataract Refract Surg     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8604171     Medline TA:  J Cataract Refract Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  225-33     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 ASCRS and ESCRS. All rights reserved.
From Beyoglu Eye Training and Research Hospital (Celik, Agca, Yilmaz), the Department of Ophthalmology (Alagoz), Mugla University, the Department of Ophthalmology (Yildirim), Kanuni Sultan Suleyman Training and Research Hospital, and the Department of Ophthalmology (Demirok), Medeniyet University, Istanbul, Turkey; the Institute of Ophthalmology (Marshall), London, United Kingdom; Avedro, Inc. (Muller), Boston, Massachusetts, USA. Electronic address:
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