Document Detail

New method of evaluating gastric mucosal blood flow by ultrasound.
MedLine Citation:
PMID:  17454863     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Evaluation of gastrointestinal blood flow is important. However, a non-invasive measurement method has not yet been established. The aim of this study was to compare measurement of normal gastric mucosal blood flow by advanced dynamic flow (ADF) flash echo imaging (FEI) with intravenous Levovist with measurement by laser Doppler flowmetry (LDF) to clarify the usefulness of ADF-FEI and thereby consider its feasibility as a non-invasive gastric mucosal blood flow measurement method. MATERIAL AND METHODS: Measurements were obtained in 25 beagle dogs (8-month-old males, body-weight, 10.6+/-1.3 kg, mean+/-SD). After insertion of a gastrointestinal endoscope, gastric mucosal blood flow at the greater curvature of the corpus was measured by LDF, and images of gastric mucosal blood flow were obtained by ADF-FEI (frequency; 4.7 MHz) with intravenous injection of Levovist (30 mg/kg). ADF-FEI images were transferred to a personal computer. A region of interest was set on the mucosa of the greater curvature of the corpus, and a time intensity curve (TIC) was plotted from the measured echo intensities. The area under the curve (AUC) calculated from the TIC and the median flow determined by LDF were analyzed and compared. RESULTS: Evaluation of normal gastric mucosal blood flow by ADF-FEI was possible in all animals. There was a strong, significant correlation between gastric mucosal blood flow measured by LDF and the AUC obtained by ADF-FEI (r=0.869, p<0.0001). CONCLUSIONS: Gastric mucosal blood flow can be accurately measured by ADF-FEI with intravenous Levovist injection.
Yutaka Mitsuoka; Jiro Hata; Ken Haruma; Noriaki Manabe; Shinji Tanaka; Kazuaki Chayama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  42     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-24     Completed Date:  2007-06-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  513-8     Citation Subset:  IM    
Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.
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MeSH Terms
Blood Flow Velocity
Contrast Media
Gastric Mucosa / blood supply*,  ultrasonography*
Image Processing, Computer-Assisted
Laser-Doppler Flowmetry
Polysaccharides / diagnostic use
Regional Blood Flow
Ultrasonography, Doppler* / methods
Reg. No./Substance:
0/Contrast Media; 0/Polysaccharides; 127279-08-7/SHU 508

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