| New members of mammalian aquaporins: AQP10-AQP12. | |
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MedLine Citation:
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PMID: 19096782 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thirteen members of mammalian aquaporins have been identified. Initial ten members (AQP-AQP9) are relatively well detailed and their roles are clarified. However, the last three members, AQP10-AQP12, are poorly characterized and little is known about their roles though they were cloned 6 years ago. In this review, we focus on these three AQPs. AQP10 is an aquaglyceroporin while AQP11 and AQP12 belong to a new subfamily, superaquaporins. Knockout mice for these aquaporins are now available. The AQP11 null mouse has a remarkable phenotype, polycystic kidneys, which is neonatally fatal. On the other hand, the absence of the other two affected little. In some animals, AQP10 is even a pseudogene. This review summarizes the current knowledge on these AQPs and will hopefully stimulate future research on the subject. |
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Authors:
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Kenichi Ishibashi |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Handbook of experimental pharmacology Volume: - ISSN: 0171-2004 ISO Abbreviation: Handb Exp Pharmacol Publication Date: 2009 |
Date Detail:
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Created Date: 2008-12-19 Completed Date: 2009-03-03 Revised Date: 2011-08-31 |
Medline Journal Info:
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Nlm Unique ID: 7902231 Medline TA: Handb Exp Pharmacol Country: Germany |
Other Details:
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Languages: eng Pagination: 251-62 Citation Subset: IM |
Affiliation:
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Department of Medical Physiology, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588, Japan. kishiba@my-pharm.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aquaglyceroporins / metabolism Aquaporins / genetics, metabolism* Gastrointestinal Tract / metabolism Genotype Humans Kidney / metabolism Mice Mice, Knockout Pancreas / metabolism Phenotype Polycystic Kidney Diseases / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/AQP10 protein, mouse; 0/AQP12 protein, mouse; 0/Aqp11 protein, mouse; 0/Aquaglyceroporins; 0/Aquaporins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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