| New medicines to improve control and contribute to the eradication of malaria. | |
| | |
MedLine Citation:
|
PMID: 19834482 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Despite being one of the most prevalent tropical diseases, for many years malaria was not a commercial priority for the pharmaceutical industry. However, in response to the emergence and spread of resistance to the available antimalarial drugs, there has been a renaissance in the discovery and development of new medicines to control the disease in the last few years. The persistent threat of resistance means that new molecules with novel mechanisms of action are continually required. Furthermore, the recent call for the elimination and eradication of malaria has prompted an extension of the stages of the life cycle of malaria parasites that should be targeted by new molecules. Recent advances in genome-based technologies and in in vitro screening of whole parasites have broadened the range of therapeutic targets and are accelerating the development of a new generation of treatments for both malaria control and eradication. |
| | |
Authors:
|
Timothy N C Wells; Pedro L Alonso; Winston E Gutteridge |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-10-16 |
Journal Detail:
|
Title: Nature reviews. Drug discovery Volume: 8 ISSN: 1474-1784 ISO Abbreviation: Nat Rev Drug Discov Publication Date: 2009 Nov |
Date Detail:
|
Created Date: 2009-10-30 Completed Date: 2009-11-16 Revised Date: 2010-07-02 |
Medline Journal Info:
|
Nlm Unique ID: 101124171 Medline TA: Nat Rev Drug Discov Country: England |
Other Details:
|
Languages: eng Pagination: 879-91 Citation Subset: IM |
Affiliation:
|
Medicines for Malaria Venture, 20 Route de Pré-Bois, 1215 Geneva, Switzerland. wellst@mmv.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antimalarials / pharmacology, therapeutic use* Drug Delivery Systems Drug Design* Drug Industry / methods Drug Resistance Humans Life Cycle Stages / drug effects Malaria / drug therapy* Plasmodium / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Antimalarials |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Explaining microbial population genomics through phage predation.
Next Document: The genetics of inbreeding depression.