| New medications which decrease levothyroxine absorption. | |
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MedLine Citation:
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PMID: 17725434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Medications may sometimes interfere with the intestinal absorption of levothyroxine, primarily by forming an insoluble complex with the thyroid hormone in the intestinal lumen. The goal of this study was to examine the acute effects of three previously unstudied medications on levothyroxine absorption. DESIGN: We studied the effects of three medications on thyroxine absorption in seven normal volunteers. On each study day, the subjects ingested 1 mg levothyroxine sodium, either taken separately or co-administered with sevelamer hydrochloride (Renagel, a phosphate-binding medication used in the treatment of hyperphosphatemia), chromium picolinate (an over-the-counter nutritional supplement), or ezetimibe (Zetia, a drug used in the treatment of hypercholesterolemia). Serum thyroxine was measured at intervals over a 6-hour period following drug ingestion. MAIN OUTCOME: Sevelamer hydrochloride and chromium picolinate each significantly (p < 0.05) decreased the area under the serum thyroxine concentration curve, while ezetimibe had no effect. CONCLUSION: Hypothyroid patients taking sevelamer hydrochloride or chromium picolinate should be advised to separate the time of ingestion of these drugs from their thyroid hormone preparation by several hours. |
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Authors:
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Jennifer John-Kalarickal; Gwen Pearlman; Harold E Carlson |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Thyroid : official journal of the American Thyroid Association Volume: 17 ISSN: 1050-7256 ISO Abbreviation: Thyroid Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-29 Completed Date: 2008-08-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9104317 Medline TA: Thyroid Country: United States |
Other Details:
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Languages: eng Pagination: 763-5 Citation Subset: IM |
Affiliation:
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Endocrinology Division, Department of Medicine, Stony Brook University School of Medicine, Stony Brook, New York 11794-8154, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anticholesteremic Agents / administration & dosage Azetidines / administration & dosage* Chelating Agents / administration & dosage Drug Interactions Female Humans Hypercholesterolemia / drug therapy Hypothyroidism / drug therapy Intestinal Absorption / drug effects* Iron Chelating Agents / administration & dosage Male Picolinic Acids / administration & dosage* Polyamines / administration & dosage* Thyroxine / blood, pharmacokinetics* |
| Grant Support | |
ID/Acronym/Agency:
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MO1RR10710/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Azetidines; 0/Chelating Agents; 0/Iron Chelating Agents; 0/Picolinic Acids; 0/Polyamines; 163222-33-1/ezetimibe; 182683-00-7/sevelamer; 7488-70-2/Thyroxine; 98-98-6/picolinic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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