| New magnetic-resonance-imaging-visible poly(ε-caprolactone)-based polyester for biomedical applications. | |
| | |
MedLine Citation:
|
PMID: 22115697 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
A great deal of effort has been made since the 1990s to enlarge the field of magnetic resonance imaging. Better tissue contrast, more biocompatible contrast agents and the absence of any radiation for the patient are some of the many advantages of using magnetic resonance imaging (MRI) rather than X-ray technology. But implantable medical devices cannot be visualized by conventional MRI and a tool therefore needs to be developed to rectify this. The synthesis of a new MRI-visible degradable polymer is described by grafting a MR contrast agent (DTPA-Gd) to a non-water-soluble, biocompatible and degradable poly(ε-caprolactone) (PCL). The substitution degree, calculated by (1)H nuclear magnetic resonance and inductively coupled plasma-mass spectrometry, is close to 0.5% and proves to be sufficient to provide a strong and clear T1 contrast enhancement. This new MRI-visible polymer was coated onto a commercial mesh for tissue reinforcement using an airbrush system and enabled in vitro MR visualization of the mesh for at least 1year. A stability study of the DTPA-Gd-PCL chelate in phosphate-buffered saline showed that a very low amount of gadolinium was released into the medium over 52weeks, guaranteeing the safety of the device. This study shows that this new MRI-visible polymer has great potential for the MR visualization of implantable medical devices and therefore the post-operative management of patients. |
| | |
Authors:
|
Sébastien Blanquer; Olivier Guillaume; Vincent Letouzey; Laurent Lemaire; Florence Franconi; Cedric Paniagua; Jean Coudane; Xavier Garric |
Related Documents
:
|
20118727 - Comparative evaluation of dynamic contrast-enhanced perfusion with diffusion tensor ima... 17032877 - Improved delineation of glioma margins and regions of infiltration with the use of diff... 7708147 - Transcallosal removal of lesions affecting the third ventricle: an anatomic and clinica... 16379577 - Spinal cord diffusion tensor imaging and fiber tracking can identify white matter tract... 3118677 - Mr imaging artifacts produced by dental materials. 12488737 - Automatic brain tissue extraction method using erosion-dilation treatment (breed) from ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-11 |
Journal Detail:
|
Title: Acta biomaterialia Volume: - ISSN: 1878-7568 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101233144 Medline TA: Acta Biomater Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
|
Max Mousseron Institute of Biomolecules (IBMM), UMR CNRS 5247, University of Montpellier 1, University of Montpellier 2, Faculty of Pharmacy, 15 Av. C. Flahault, Montpellier F34093, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Elastic moduli of untreated, demineralized and deproteinized cortical bone: Validation of a theoreti...
Next Document: Implementation of 24/7 radiology services in an academic medical centre level 1 trauma centre: Impac...