Document Detail

New losartan-hydrocaffeic acid hybrids as antihypertensive-antioxidant dual drugs: Ester, amide and amine linkers.
MedLine Citation:
PMID:  22336384     Owner:  NLM     Status:  Publisher    
We report new examples of a series of losartan-hydrocaffeic hybrids that bear novel ester, amide and amine linkers. These compounds were made by linking hydrocaffeic acid to the side chain of losartan at the C-5 position of the imidazole ring through different strategies. Experiments performed in cultured cells demonstrate that these new hybrids retain the ability to block the angiotensin II effect and have increased antioxidant ability. Most of them reduced arterial pressure in rats better or as much as losartan.
Gonzalo García; Isabel Serrano; Patricia Sánchez-Alonso; Manuel Rodríguez-Puyol; Ramón Alajarín; Mercedes Griera; Juan J Vaquero; Diego Rodríguez-Puyol; Julio Alvarez-Builla; María L Díez-Marqués
Related Documents :
9720244 - Identification of n epsilon-[(r)-1-carboxyethyl]-l-lysine in, and the complete structur...
7512444 - The structure of the o-specific polysaccharide of salmonella arizonae o62.
2223004 - Structural analysis of the specific capsular polysaccharide of rhodococcus equi serotyp...
8593624 - Structures of decasaccharide and tridecasaccharide tetraphosphates isolated by strong a...
19939484 - Isolation and characterization of plantaricin asm1: a new bacteriocin produced by lacto...
1199614 - Studies on the synthesis of liver phospholipids and the turnover of plasma phospholipid...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-30
Journal Detail:
Title:  European journal of medicinal chemistry     Volume:  -     ISSN:  1768-3254     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-2-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0420510     Medline TA:  Eur J Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
Departamento de Química Orgánica, Facultad de Química, Universidad de Alcalá, Campus Universitario, 28871-Alcalá de Henares, Madrid, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Have biopesticides come of age?
Next Document:  1,3,4-Thiadiazole derivatives as selective inhibitors of iNOS versus nNOS: Synthesis and structure-a...