Document Detail

New long-chain aliphatic compounds from Peperomia dindygulensis.
MedLine Citation:
PMID:  22780426     Owner:  NLM     Status:  Publisher    
Three long-chain aliphatic compounds, including one new polyketide derivative, dindygulerione C (1), one new octaketide derivative, dindygulerione D (2) and one new acylresorcinol derivative dindyguleranone (3) were isolated from the whole plant of the Chinese anticancer folk medicine Peperomia dindygulensis Miq. (Piperaceae). Dindygulerione C is an unprecedented example of a N-containing polyketide. The chemical structures and configurations of 1-3 were elucidated as (-)-(4S)-2-[(Z)-1'-(6″,7″-dihydroxyphenethyl-amino)octadec-11'-enylidene]-4-hydroxycyclohexane-1,3-dione (1), (+)-2-heptadecyl-4-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-one (2) and 2-(1,3-dihydroxyphenyl)-octacosan-1'-one (3), respectively, by comparing with the literature data and extensive spectroscopic methods, including 2-D NMR and circular dichroism spectroscopic analysis. The cytotoxicity of 1-3 was evaluated against Hep3B and HepG2 liver cancer cell lines.
Xinzhi Wang; Wei Qu; Jingyu Liang
Related Documents :
17432886 - Stereospecific morphogenesis of aspartic acid helical crystals through molecular recogn...
18605706 - Matrix-mediated formation of hierarchically structured sno crystals as intermediates be...
17930766 - Evidence for out-of-equilibrium crystal nucleation in suspensions of oppositely charged...
16022646 - Pathological mineralization of cardiac valves: causes and mechanism.
11254346 - Electron-transfer-induced molecular reorientations: the benzoquinone/hydroquinone react...
15004386 - Melaminium maleate monohydrate.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-10
Journal Detail:
Title:  Natural product research     Volume:  -     ISSN:  1478-6427     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101167924     Medline TA:  Nat Prod Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a Department of Natural Medicinal Chemistry , China Pharmaceutical University , Nanjing 210009 , P.R. China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Short-term intravenous insulin infusion is associated with reduced expression of NADPH oxidase p47(p...
Next Document:  Unique Ring Families: A Chemically Meaningful Description of Molecular Ring Topologies.