Document Detail


New light on early post-implantation pregnancy in the mouse: roles for insulin-like growth factor-II (IGF-II)?
MedLine Citation:
PMID:  16824595     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Successful placental development and the associated changes to the decidual vasculature during early pregnancy are critical to pregnancy outcome. This study utilised immunohistochemistry to provide a photomicrographic account of trophoblast invasion, as well as the changes in the uterine vasculature in the decidua from days 5.5 to 10.5 of murine pregnancy. The pattern of trophoblast invasion during this time is particularly interesting because, unlike in humans, murine trophoblast giant cells (TGCs) do not invade the endometrium individually but remain in close contact with the expanding giant cell layer. Therefore, trophoblast cells are unlikely to play a direct role in remodelling the maternal vessels in early to mid pregnancy. Nevertheless, the decidual vessels appear to undergo extensive angiogenesis and remodelling to form a network of dilated vessels that presumably maximize placental blood supply. Importantly, the vessels closest to the conceptus lacked a smooth muscle layer throughout early pregnancy and therefore cannot strictly be described as spiral arterioles. TGCs may secrete molecules that can act to induce these vascular changes. Here we show that insulin-like growth factor-II (IGF-II) is expressed throughout early pregnancy in the entire conceptus including trophoblast cells, supporting its role in promoting early placental growth. In addition, the co-localisation of IGF-II and both IGF receptors in the developing blood vessels and/or adjacent stromal cells in the mesometrial, but not in the anti-mesometrial, decidua suggest that IGF-II, upon binding to one of these receptors, may play a role in both decidual angiogenesis and placental differentiation.
Authors:
K G Pringle; C T Roberts
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-07-07
Journal Detail:
Title:  Placenta     Volume:  28     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-06     Completed Date:  2007-05-29     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  286-97     Citation Subset:  IM    
Affiliation:
Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, SA 5005, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blastocyst / cytology,  metabolism*
Blood Vessels / cytology,  growth & development
Decidua / blood supply,  metabolism*
Embryo Implantation / physiology*
Endothelium, Vascular / cytology,  metabolism
Female
Insulin-Like Growth Factor II / metabolism*
Mice
Neovascularization, Physiologic / physiology
Receptor, IGF Type 1 / metabolism
Receptor, IGF Type 2 / metabolism
Trophoblasts / metabolism*
Grant Support
ID/Acronym/Agency:
U01 HD044664-01/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Receptor, IGF Type 2; 67763-97-7/Insulin-Like Growth Factor II; EC 2.7.10.1/Receptor, IGF Type 1

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