Document Detail

New kinetic models for the hepatitis C virus.
MedLine Citation:
PMID:  16175615     Owner:  NLM     Status:  MEDLINE    
Viral kinetic modeling has played an important role in the analysis of HCV RNA decay after the initiation of antiviral therapy. Models have provided a means of evaluating the antiviral effectiveness of therapy, of estimating parameters such as the rate of virion clearance and the rate of clearance of hepatitis C virus (HCV)-infected cells, and they have suggested mechanisms of action for both interferon and ribavirin. Nevertheless, the models that were originally formulated were unable to explain all of the observed HCV RNA profiles. We provide an update on the state of HCV kinetic modeling and discuss new models that have taken into consideration the different pharmacokinetics of standard and pegylated forms of interferon, allow for changes in drug effectiveness as drug concentrations fall between dosing intervals, and that have incorporated alanine aminotransferase kinetics and aspects of immune responses to provide a more comprehensive picture of the biology underlying changes in HCV RNA during therapy.
Alan S Perelson; Eva Herrmann; Florence Micol; Stefan Zeuzem
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  42     ISSN:  0270-9139     ISO Abbreviation:  Hepatology     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-26     Completed Date:  2005-11-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  749-54     Citation Subset:  IM    
Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87525, USA.
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MeSH Terms
Antiviral Agents / therapeutic use*
Hepacivirus / drug effects*,  growth & development
Hepatitis C / drug therapy*,  virology*
Models, Biological*
Grant Support
Reg. No./Substance:
0/Antiviral Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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