Document Detail

New instrumentation for determining flexure breaking strength of capsule-shaped tablets.
MedLine Citation:
PMID:  7373529     Owner:  NLM     Status:  MEDLINE    
New instrumentation to measure the flexure breaking strength of capsule-shaped tablets was developed. It consisted of a mechanical linkage to apply the breaking load at a uniform rate and a strain-gauge instrumented cantilever beam to convert the load to a proportional millivolt response on a recorder. A recorder tracing was obtained of increasing load with time, with a break in the tracing denoting the tablet's flexure breaking strength. Measurements were made for different tablet hardnesses, and a plot of tablet hardness versus flexure breaking strength yielded a profile of the mechanical strength of the tablet. The instrumentation was shown to have application for determining the effects of tablet thicknesses, tablet ingredients, tablet sizes, cup depths, and bisect dimensions on tablet strength.
G Gold; R N Duvall; B T Palermo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  69     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-07-22     Completed Date:  1980-07-22     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  384-6     Citation Subset:  IM    
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MeSH Terms
Hardness Tests / instrumentation*
Tablets / standards*
Technology, Pharmaceutical
Reg. No./Substance:
0/Capsules; 0/Tablets

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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