Document Detail


New insights into the transmission biology of urinary schistosomiasis in Zanzibar.
MedLine Citation:
PMID:  12474469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A better understanding of the transmission biology of urinary schistosomiasis in Zanzibar, Tanzania was only possible after the development of molecular DNA markers for identification of Bulinus africanus group snails, the potential intermediate hosts of Schistosoma haematobium. Hitherto, identification of natural populations of B. globosus and B. nasutus was problematic and the intermediate host status and distribution of either species remained speculative. By recourse to molecular markers, snail distribution maps could be drawn, revealing an allopatric distribution and, more importantly, leading to the discovery that B. nasutus played no role in transmission. Indeed, in Unguja the area of active transmission of S. haematobium to humans is confined within the distribution of B. globosus. This strong relationship may prove useful for predicting the distribution of urinary schistosomiasis within Zanzibar and, if snail schistosome compatibilities persist, in other areas nearby, e.g. coastal Tanzania and Kenya. The transmission biology of urinary schistosomiasis in Zanzibar is reviewed, the paper reports on ongoing malacological studies in Zanzibar and Kenya and finally closes by posing the question whether medical malacology forms an essential component associated with mass-scale chemotherapy control programmes.
Authors:
J R Stothard; A F Mgeni; S Khamis; E Seto; M Ramsan; S J Hubbard; T K Kristensen; D Rollinson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transactions of the Royal Society of Tropical Medicine and Hygiene     Volume:  96     ISSN:  0035-9203     ISO Abbreviation:  Trans. R. Soc. Trop. Med. Hyg.     Publication Date:    2002 Sep-Oct
Date Detail:
Created Date:  2002-12-11     Completed Date:  2003-01-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506129     Medline TA:  Trans R Soc Trop Med Hyg     Country:  England    
Other Details:
Languages:  eng     Pagination:  470-5     Citation Subset:  IM    
Affiliation:
Wolfson Wellcome Biomedical Laboratories, Biomedical Parasitology Division, Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK. r.stothard@nhm.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Bulinus / parasitology
DNA, Helminth / analysis
Endemic Diseases
Humans
Polymerase Chain Reaction / methods
Schistosoma haematobium / isolation & purification
Schistosomiasis haematobia / epidemiology,  prevention & control,  transmission*
Tanzania / epidemiology
Chemical
Reg. No./Substance:
0/DNA, Helminth

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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