| New insights into the role of thyroid hormone in cardiac remodeling: time to reconsider? | |
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MedLine Citation:
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PMID: 20668933 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Chronic ischemia or pressure overload decreases thyroid hormone (TH) signaling and activates the fetal gene program in the heart. While these features are of physiologic importance in the developing heart, their respective roles in the postnatal heart are debated. Administration of TH can prevent the changes of the fetal gene program and rebuild the heart after an "index event" such as ischemia. TH affects cardiac remodeling by limiting reperfusion injury, and, at later states, by inducing distinct changes in cardiac chamber geometry in a time-dependent manner. Furthermore, administration of TH can convert pathologic to physiologic hypertrophy. These effects are the result of favorable cellular remodeling. While preliminary clinical studies provide encouraging results, the potential and efficacy of TH in the treatment of heart disease still await evaluation in large clinical trials. |
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Authors:
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Constantinos Pantos; Iordanis Mourouzis; Dennis V Cokkinos |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Heart failure reviews Volume: 16 ISSN: 1573-7322 ISO Abbreviation: Heart Fail Rev Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9612481 Medline TA: Heart Fail Rev Country: United States |
Other Details:
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Languages: eng Pagination: 79-96 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Athens, 75 Mikras Asias Ave., 11527, Goudi, Athens, Greece. cpantos@med.uoa.gr |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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