Document Detail


New insights into the role of angiotensin-converting enzyme obtained from the analysis of genetically modified mice.
MedLine Citation:
PMID:  18443752     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Angiotensin-converting enzyme (ACE) has been well-recognized for its role in blood pressure regulation. ACE is made by many tissues, though it is most abundantly expressed on the luminal surface of vascular endothelium. ACE knockout mice show a profound phenotype with low blood pressure, but also with hemopoietic and developmental defects, which complicates understanding the biological functions of ACE in individual tissue types. Using a promoter-swapping strategy, several mouse lines with unique ACE tissue expression patterns were studied. These include mice with ACE expression in the liver (ACE 3/3), the heart (ACE 8/8), and macrophages (ACE 10/10). We also investigated mice with a selective inactivation of either the N- or C-terminal ACE catalytic domain. Our studies indicate that ACE plays a role in many other physiologic processes beyond simple blood pressure control.
Authors:
Xiao Z Shen; Hong D Xiao; Ping Li; Chentao X Lin; Sandrine Billet; Derick Okwan-Duodu; Jon W Adams; Ellen A Bernstein; Yi Xu; Sebastien Fuchs; Kenneth E Bernstein
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2008-04-29
Journal Detail:
Title:  Journal of molecular medicine (Berlin, Germany)     Volume:  86     ISSN:  0946-2716     ISO Abbreviation:  J. Mol. Med.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-09     Completed Date:  2008-09-05     Revised Date:  2011-07-08    
Medline Journal Info:
Nlm Unique ID:  9504370     Medline TA:  J Mol Med (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  679-84     Citation Subset:  IM    
Affiliation:
Department of Pathology, Emory University, 101 Woodruff Circle, Atlanta, GA 30322, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Catalytic Domain
Macrophages / enzymology
Mice
Mice, Knockout
Mutation / genetics
Organ Specificity
Peptidyl-Dipeptidase A / chemistry,  genetics,  metabolism*
Grant Support
ID/Acronym/Agency:
K99 HL 088000/HL/NHLBI NIH HHS; R01 DK 039777/DK/NIDDK NIH HHS; R01 DK 051445/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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