| New insights into the regulation and cellular functions of the ARP2/3 complex. | |
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MedLine Citation:
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PMID: 23212475 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The actin-related protein 2/3 (ARP2/3) complex nucleates branched actin filament networks, but requires nucleation promoting factors (NPFs) to stimulate this activity. NPFs include proteins such as Wiskott-Aldrich syndrome protein (WASP), neural WASP (NWASP), WASP family verprolin-homologous protein (WAVE; also known as SCAR) and the recently identified WASP and SCAR homologue (WASH) complex. The mechanisms underlying NPF-dependent regulation and the cellular functions of ARP2/3 are being unravelled using new chemical and genetic approaches. Of particular interest is the role of the ARP2/3 complex in vesicular trafficking and directional cell motility. |
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Authors:
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Jeremy D Rotty; Congying Wu; James E Bear |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-05 |
Journal Detail:
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Title: Nature reviews. Molecular cell biology Volume: - ISSN: 1471-0080 ISO Abbreviation: Nat. Rev. Mol. Cell Biol. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100962782 Medline TA: Nat Rev Mol Cell Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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UNC Lineberger Comprehensive Cancer Center, Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA; and at the Howard Hughes Medical Institute. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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