| [New insights into the pathophysiology of oedema in nephrotic syndrome]. | |
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MedLine Citation:
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PMID: 21461007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oedema is a common clinical manifestation of nephrotic syndrome. However, the pathophysiological mechanism of sodium retention in nephrotic syndrome has been intensely debated for decades. Several clinical and experimental observations argue against the classic or "underfill" hypothesis of oedema formation in nephrotic syndrome. In many patients, oedema formation in nephrotic syndrome is due to the kidney being intrinsically unable to excrete salt and is unrelated to systemic factors (i.e. hypoalbuminaemia, decreased “effective” arterial blood volume, and secondary hyperaldosteronism). The cortical collecting duct is the nephron site of sodium retention in nephrotic syndrome. Activation of the epithelial sodium channel in the cortical collecting duct is responsible for sodium retention in nephrotic syndrome. In nephrotic syndrome, a defective glomerular filtration barrier allows the passage of proteolytic enzymes or their precursors, which have the ability to activate the epithelial sodium channel, thereby causing the the subsequent sodium retention and oedema. |
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Authors:
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H Rondon-Berrios |
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Publication Detail:
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Type: English Abstract; Journal Article; Review |
Journal Detail:
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Title: Nefrología : publicación oficial de la Sociedad Española Nefrologia Volume: 31 ISSN: 1989-2284 ISO Abbreviation: Nefrologia Publication Date: 2011 |
Date Detail:
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Created Date: 2011-04-04 Completed Date: 2011-08-23 Revised Date: 2011-11-03 |
Medline Journal Info:
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Nlm Unique ID: 8301215 Medline TA: Nefrologia Country: Spain |
Other Details:
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Languages: spa Pagination: 148-54 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of New Mexico School of Medicine, University of New Mexico, Albuquerque, New Mexico, USA.HRondon@salud.unm.edu |
Vernacular Title:
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Avances en la fisiopatología del edema en el síndrome nefrótico. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amiloride
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pharmacology,
therapeutic use Animals Diet, Sodium-Restricted Disease Models, Animal Dogs Edema / diet therapy, drug therapy, etiology, physiopathology* Epithelial Sodium Channel / antagonists & inhibitors, metabolism* Humans Hypoalbuminemia / physiopathology Kidney Glomerulus / physiopathology* Kidney Tubules, Collecting / metabolism* Natriuresis / drug effects Nephrotic Syndrome / complications*, metabolism Proteinuria / etiology, physiopathology Rats Rats, Mutant Strains Serine Proteases / physiology, urine Sodium / metabolism* Sodium-Hydrogen Antiporter / metabolism Sodium-Potassium-Exchanging ATPase / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Epithelial Sodium Channel; 0/Sodium-Hydrogen Antiporter; 0/sodium-hydrogen exchanger 3; 2609-46-3/Amiloride; 7440-23-5/Sodium; EC 3.4.-/Serine Proteases; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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