Document Detail


New insights into the pathogenesis of cellular crescents.
MedLine Citation:
PMID:  21455064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: This review discusses the recent evidence that intrinsic glomerular cells including podocytes, parietal epithelial cells and progenitor cells within Bowman's capsule contribute to cellular crescents.
RECENT FINDINGS: Using a variety of newer molecular markers and lineage tracing experiments, investigators have clearly demonstrated that glomerular cells play a key role in the development and progression of cellular crescents in experimental and human disease.
SUMMARY: Crescentic glomerulonephritis is associated with significant morbidity and mortality. Current therapies target the immune system. The recent finding that nonimmune cells also play a role in crescent formation highlights the need to identify alternate and complimentary therapeutic strategies.
Authors:
Sunita K S Singh; Marie Jeansson; Susan E Quaggin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in nephrology and hypertension     Volume:  20     ISSN:  1473-6543     ISO Abbreviation:  Curr. Opin. Nephrol. Hypertens.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-14     Completed Date:  2011-08-15     Revised Date:  2013-05-02    
Medline Journal Info:
Nlm Unique ID:  9303753     Medline TA:  Curr Opin Nephrol Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  258-62     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bowman Capsule / pathology*
Glomerulonephritis / etiology*,  pathology
Humans
Intermediate Filament Proteins / physiology
Mice
Nerve Tissue Proteins / physiology
Podocytes / physiology*
Stem Cells / physiology
Grant Support
ID/Acronym/Agency:
62931//Canadian Institutes of Health Research; MOP 77756//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Intermediate Filament Proteins; 0/Nerve Tissue Proteins; 0/nestin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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