Document Detail

New insights into the molecular mechanisms of mitosis and cytokinesis in trypanosomes.
MedLine Citation:
PMID:  24411171     Owner:  NLM     Status:  In-Data-Review    
Trypanosoma brucei, a unicellular eukaryote and the causative agent of human sleeping sickness, possesses multiple single-copy organelles that all need to be duplicated and segregated during cell division. Trypanosomes undergo a closed mitosis in which the mitotic spindle is anchored on the nuclear envelope and connects the kinetochores made of novel protein components. Cytokinesis in trypanosomes is initiated from the anterior tip of the new flagellum attachment zone, and proceeds along the longitudinal axis without the involvement of the actomyosin contractile ring, the well-recognized cytokinesis machinery conserved from yeast to humans. Trypanosome appears to employ both evolutionarily conserved and trypanosome-specific proteins to regulate its cell cycle, and has evolved certain cell cycle regulatory pathways that are either distinct between its life cycle stages or different from its human host. Understanding the mechanisms of mitosis and cytokinesis in trypanosomes not only would shed novel light on the evolution of cell cycle control, but also could provide new drug targets for chemotherapy.
Qing Zhou; Huiqing Hu; Ziyin Li
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International review of cell and molecular biology     Volume:  308     ISSN:  1937-6448     ISO Abbreviation:  Int Rev Cell Mol Biol     Publication Date:  2014  
Date Detail:
Created Date:  2014-01-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101475846     Medline TA:  Int Rev Cell Mol Biol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  127-66     Citation Subset:  IM    
Copyright Information:
© 2014 Elsevier Inc. All rights reserved.
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