Document Detail

New insights into the mechanisms and sites of action of lamotrigine.
MedLine Citation:
PMID:  11093067     Owner:  NLM     Status:  MEDLINE    
This study was aimed at investigating the effects of lamotrigine (LTG) on electrically evoked field excitatory postsynaptic potentials (fEPSP) and population spikes in the CA1 hippocampal region of guinea pigs. The concentration response curves showed different actions of LTG on fEPSP and on population spikes. The data are in contrast to previous findings that suggest the drug acts primarily on presynaptic sites via a blockade of the release of excitatory amino acids. In the range of therapeutic plasma levels, synaptic transmission was not affected.
J M Langosch; X Y Zhou; H Grunze; J Walden
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuropsychobiology     Volume:  42 Suppl 1     ISSN:  0302-282X     ISO Abbreviation:  Neuropsychobiology     Publication Date:  2000  
Date Detail:
Created Date:  2001-02-05     Completed Date:  2001-02-08     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  7512895     Medline TA:  Neuropsychobiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  26-7     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel.
Department of Psychiatry, University of Freiburg Medical School, Freiburg i.Br., Germany.
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MeSH Terms
Anticonvulsants / pharmacology*
Dendrites / drug effects
Electric Stimulation
Excitatory Postsynaptic Potentials / drug effects
Guinea Pigs
Hippocampus / drug effects*
Pyramidal Cells / drug effects
Triazines / pharmacology*
Reg. No./Substance:
0/Anticonvulsants; 0/Triazines; U3H27498KS/lamotrigine

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