Document Detail


New insights into the mechanisms and sites of action of lamotrigine.
MedLine Citation:
PMID:  11093067     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was aimed at investigating the effects of lamotrigine (LTG) on electrically evoked field excitatory postsynaptic potentials (fEPSP) and population spikes in the CA1 hippocampal region of guinea pigs. The concentration response curves showed different actions of LTG on fEPSP and on population spikes. The data are in contrast to previous findings that suggest the drug acts primarily on presynaptic sites via a blockade of the release of excitatory amino acids. In the range of therapeutic plasma levels, synaptic transmission was not affected.
Authors:
J M Langosch; X Y Zhou; H Grunze; J Walden
Related Documents :
6442397 - Glycine potentiates the action of some anticonvulsant drugs in some seizure models.
1970947 - Posterior midbrain-induced locomotion.
22909127 - Silver-catalyzed decarboxylative alkynylation of aliphatic carboxylic acids in aqueous ...
10049227 - Excitatory amino acid neurotransmission in the primary gustatory nucleus of the goldfis...
29457 - Interaction between pco2 and plasma [hco-3] in regulation of csf [hco-3] in respiratory...
7812727 - The effect of the sweetness inhibitor 2(-4-methoxyphenoxy)propanoic acid (sodium salt) ...
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuropsychobiology     Volume:  42 Suppl 1     ISSN:  0302-282X     ISO Abbreviation:  Neuropsychobiology     Publication Date:  2000  
Date Detail:
Created Date:  2001-02-05     Completed Date:  2001-02-08     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  7512895     Medline TA:  Neuropsychobiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  26-7     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel.
Affiliation:
Department of Psychiatry, University of Freiburg Medical School, Freiburg i.Br., Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Anticonvulsants / pharmacology*
Dendrites / drug effects
Electric Stimulation
Excitatory Postsynaptic Potentials / drug effects
Guinea Pigs
Hippocampus / drug effects*
Pyramidal Cells / drug effects
Triazines / pharmacology*
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Triazines; U3H27498KS/lamotrigine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Association study of suicidal behavior and affective disorders with a genetic polymorphism in ABCG1,...
Next Document:  Modulation of neural cell membrane conductance by the herbal anxiolytic and antiepileptic drug aswal...