Document Detail

New insights into the importance of aminopeptidase A in hypertension.
MedLine Citation:
PMID:  17990103     Owner:  NLM     Status:  MEDLINE    
The renin-angiotensin system (RAS) plays an important role in the maintenance of normal blood pressure and the etiology of hypertension; however, minimal attention has been paid to the degradation of the effector peptide, angiotensin II (AngII). Since aminopeptidase A (APA)-deficient mice develop hypertension APA appears to be an essential enzyme in the control of blood pressure via degradation of AngII. The robust hypertension seen in the spontaneously hypertensive rat (SHR) is due to activation of the RAS, and an accompanying decrease in kidney APA. Changes in APA have also been measured during the activation of the RAS in the Goldblatt hypertension model and Dahl salt-sensitive (DSS) rat. The DSS rat shows an elevation in renal APA activity at the onset of hypertension suggesting a protective role against elevations in circulating AngII, followed by decreased APA activity with advancing hypertension. Changes seen in human maternal serum APA activity during preeclampsia are similar to changes measured in renal APA in the DSS rat model. APA activity is higher than during normal pregnancy at the onset of preeclampsia, and with advancing preeclampsia (severe preeclampsia) declines below that seen during normal pregnancy. Serum APA activity is also increased during hormone replacement therapy (HRT), perhaps in reaction to elevated levels of AngII. Thus, it appears important to consider the relationship among activation of the RAS, circulating levels of AngII, and the availability of APA in hypertensive disorders.
Shigehiko Mizutani; Masakazu Ishii; Akira Hattori; Seiji Nomura; Yasushi Numaguchi; Masafumi Tsujimoto; Hiroshi Kobayshi; Toyoaki Murohara; John W Wright
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-11-08
Journal Detail:
Title:  Heart failure reviews     Volume:  13     ISSN:  1382-4147     ISO Abbreviation:  Heart Fail Rev     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-04-14     Completed Date:  2008-08-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612481     Medline TA:  Heart Fail Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  273-84     Citation Subset:  IM    
Department of Medical Science of Proteases, Nagoya University, Graduate School of Medicine, Nagoya, Japan.
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MeSH Terms
Angiotensin II / metabolism
Antihypertensive Agents / pharmacology,  therapeutic use
Glutamyl Aminopeptidase / metabolism*
Hypertension / drug therapy,  metabolism*,  physiopathology
Pre-Eclampsia / enzymology,  metabolism,  pathology
Renin-Angiotensin System / drug effects
Reg. No./Substance:
0/Antihypertensive Agents; 11128-99-7/Angiotensin II; EC Aminopeptidase

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