| New insights into hypertension-associated erectile dysfunction. | |
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MedLine Citation:
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PMID: 22240443 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Erectile dysfunction is recognized as a quality-of-life disorder that needs to be treated. Currently, it is estimated to affect as many as 30 million American men. Thirty percent of hypertensive patients complain of erectile dysfunction. The understanding of common mechanisms involved in the cause of erectile dysfunction associated with hypertension, and the investigation of antihypertensive drugs that impact erectile dysfunction, will provide important tools toward identifying new therapeutic targets that will improve the quality of life for patients in these conditions. RECENT FINDINGS: Hypertension and erectile dysfunction are closely intertwined diseases, which have endothelial dysfunction as a common base. During hypertension and/or erectile dysfunction, disturbance of endothelium-derived factors can lead to an increase in vascular smooth muscle (VSM) contraction. Hypertension can lead to erectile dysfunction as a consequence of high blood pressure (BP) or due to antihypertensive treatment. However, growing evidence suggests erectile dysfunction is an early sign for hypertension. Also, some phosphodiesterase-5 inhibitors used to treat erectile dysfunction can improve BP, but the link between these conditions has not been totally understood. SUMMARY: This review will discuss the interplay between hypertension and erectile dysfunction, exploring newest insights regarding hypertension-associated erectile dysfunction, as well as the effect of antihypertensive drugs in erectile dysfunction patients. |
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Authors:
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Kenia Pedrosa Nunes; Hicham Labazi; R Clinton Webb |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Current opinion in nephrology and hypertension Volume: 21 ISSN: 1473-6543 ISO Abbreviation: Curr. Opin. Nephrol. Hypertens. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-08 Completed Date: 2012-06-04 Revised Date: 2013-05-02 |
Medline Journal Info:
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Nlm Unique ID: 9303753 Medline TA: Curr Opin Nephrol Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 163-70 Citation Subset: IM |
Affiliation:
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Department of Physiology, Georgia Health Sciences University, Georgia, Augusta, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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pharmacology Endothelium, Vascular / pathology, physiopathology Erectile Dysfunction / complications*, drug therapy, physiopathology Humans Hypertension / complications*, physiopathology Male Muscle Contraction Muscle, Smooth, Vascular / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK083685/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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