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New insights into germ cell migration and survival/apoptosis in spermatogenesis: Lessons from CD147.
MedLine Citation:
PMID:  23248767     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
CD147, also named basigin (Bsg) or extracellular matrix (ECM) metalloproteinase inducer (EMMPRIN), is a highly glycosylated protein first identified as a tumor cell surface molecule. In cancer, it is well established that CD147 promotes metastasis by stimulating the production of MMPs. Recent studies have also suggested that it may be associated with tumor growth and angiogenesis. Interestingly, CD147 is expressed in germ cells of different development stages in the testis and its knockout mice are infertile, indicating an essential role of CD147 in spermatogenesis. While the detailed involvement of CD147 in spermatogenesis remains elusive, our recent findings have revealed a dual role of CD147 in germ cell development. On the one hand, it regulates the migration of spermatogonia and spermatocytes via the induction of MMP-2 production; on the other hand, it specifically regulates the survival/apoptosis of spermatocytes but not spermatogonia through a p53-independent pathway. In this review, we aim to provide an overview on the functions of CD147, comparing its roles in cancer and the testis, thereby providing new insights into the regulatory mechanisms underlying the process of spermatogenesis.
Authors:
Hao Chen; Kin Lam Fok; Xiaohua Jiang; Hsiao Chang Chan
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Spermatogenesis     Volume:  2     ISSN:  2156-5554     ISO Abbreviation:  Spermatogenesis     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-12-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101543545     Medline TA:  Spermatogenesis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  264-272     Citation Subset:  -    
Affiliation:
The Second People's Hospital of Shenzhen; The First Affiliated Hospital of Shenzhen University; Shenzhen, P.R. China ; Epithelial Cell Biology Research Center; School of Biomedical Sciences; Faculty of Medicine; The Chinese University of Hong Kong; Shatin, Hong Kong.
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