| New insights into fragile X syndrome: from molecules to neurobehaviors. | |
| | |
MedLine Citation:
|
PMID: 12633995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Fragile X syndrome - a common form of inherited mental retardation - is caused by the loss of the fragile X mental retardation 1 protein (FMRP). FMRP is an RNA-binding protein which forms a messenger ribonucleoprotein (mRNP) complex that associates with translating polyribosomes. It has been proposed that FMRP is involved in synaptic plasticity through the regulation of mRNA transportation and translation. Recent advances in the identification of the mRNA ligands that are bound by FMRP, the RNA sequence and structure required for FMRP-RNA interaction, and the physiological consequences of FMRP deficiency in the brain are important steps towards understanding the molecular pathogenesis of fragile X syndrome, and learning and memory in general. |
| | |
Authors:
|
Peng Jin; Stephen T Warren |
Related Documents
:
|
19117905 - Advances in the treatment of fragile x syndrome. 19471185 - Levetiracetam improves intention tremor in fragile x-associated tremor/ataxia syndrome. 22537195 - Targeting matrix metalloproteinases in acute inflammatory shock syndromes. 17542655 - Receptive vocabulary, expressive vocabulary, and speech production of boys with fragile... 20420025 - Partial trisomy due to a de novo duplication 22q11.1-22q13.1: a cat-eye syndrome varian... 9396195 - Sneddon's syndrome in a patient with homonymous hemianopia with macular sparing. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Trends in biochemical sciences Volume: 28 ISSN: 0968-0004 ISO Abbreviation: Trends Biochem. Sci. Publication Date: 2003 Mar |
Date Detail:
|
Created Date: 2003-03-13 Completed Date: 2003-07-08 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7610674 Medline TA: Trends Biochem Sci Country: England |
Other Details:
|
Languages: eng Pagination: 152-8 Citation Subset: IM |
Affiliation:
|
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Brain / physiopathology Cell Nucleus / metabolism Fragile X Mental Retardation Protein Fragile X Syndrome* / genetics, metabolism, pathology, physiopathology Humans Nerve Tissue Proteins / chemistry, genetics, metabolism* Neuronal Plasticity Neurons / metabolism* Nucleic Acid Conformation Protein Biosynthesis RNA, Messenger / chemistry, metabolism RNA-Binding Proteins* |
| Grant Support | |
ID/Acronym/Agency:
|
P01 HD35576/HD/NICHD NIH HHS; R37HD20521/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/FMR1 protein, human; 0/Nerve Tissue Proteins; 0/RNA, Messenger; 0/RNA-Binding Proteins; 139135-51-6/Fragile X Mental Retardation Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Heparan sulfate proteoglycan as a plasma membrane carrier.
Next Document: mRNA display: ligand discovery, interaction analysis and beyond.