Document Detail

New insights into the effects of age and sex on arterial baroreflex function at rest and during dynamic exercise in humans.
MedLine Citation:
PMID:  23151515     Owner:  NLM     Status:  MEDLINE    
The arterial baroreflex (ABR) performs an important role in regulating blood pressure (BP) both at rest and during exercise, by carefully orchestrating autonomic neural activity to the heart and blood vessels. Reduced ABR sensitivity (i.e., gain) has been associated with increased cardiovascular risk, cardiac electrical instability and orthostatic intolerance, while 'normal' ABR function during exercise is important for ensuring an appropriate cardiovascular response is elicited. Previous studies examining the influence of age and sex on resting ABR function in humans have primarily used pharmacological methods (e.g., modified Oxford technique) to change BP and alter baroreceptor input. With this approach only reflex control of heart rate and sympathetic nerve activity may be evaluated, and as such the influence of age and sex on ABR control of BP per se remains incompletely understood. Furthermore, the majority of previous studies examining ABR function during exercise have principally assessed young men. Whether these findings can be extrapolated to young women or older men and women remains unclear. Recently the potential for age and sex to modulate the integrative neural control of the cardiovascular system is becoming appreciated. This review article will provide a detailed update of such recent advances into our understanding of the effects of age and sex on ABR control of BP both at rest and during dynamic exercise in humans.
James P Fisher; Areum Kim; Doreen Hartwich; Paul J Fadel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-11-11
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  172     ISSN:  1872-7484     ISO Abbreviation:  Auton Neurosci     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-05-02     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  13-22     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Age Factors
Arteries / growth & development,  innervation,  physiology*
Autonomic Nervous System / physiology*
Cardiovascular Physiological Phenomena*
Cardiovascular System / growth & development,  innervation
Estrogens / metabolism
Motor Activity*
Progesterone / metabolism
Sex Characteristics
Grant Support
Reg. No./Substance:
0/Estrogens; 4G7DS2Q64Y/Progesterone

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