Document Detail

New insights in segmental vitiligo: case report and review of theories.
MedLine Citation:
PMID:  21936857     Owner:  NLM     Status:  Publisher    
Segmental vitiligo and generalized vitiligo are in general considered to be separate entities. The etiopathogenesis of segmental vitiligo remains unclear, although several hypotheses have been put forward including mainly neuronal mechanisms. The typical association with other auto-immune diseases as seen in generalized vitiligo, seems to be significantly less in segmental vitiligo, although recent insights point towards a possible immune mediated overlap between the two subtypes. In this article, we describe a case with simultaneous presence of segmental vitiligo, alopecia areata, psoriasis and a halo nevus. To our knowledge, this is the first case with this exceptional combination. This concomitant presence could support the involvement of a shared auto-immune mediated process, may provide new insights in the pathogenesis of segmental vitiligo and direct future research. In the light of this remarkable case, different possible etiopathogenetic mechanisms leading to the clinical presentation of segmental vitiligo are discussed and a new 3 step theory is proposed.
N van Geel; I Mollet; L Brochez; M Dutré; S De Schepper; E Verhaeghe; J Lambert; R Speeckaert
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-21
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 British Association of Dermatologists.
Department of Dermatology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium.
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