Document Detail


New insights in research about acute ischemic myocardial injury and inflammation.
MedLine Citation:
PMID:  23286292     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recognition that inflammation may contribute to the pathogenesis of various cardiac diseases has naturally led to the evaluation of the therapeutic potential of a range of anti-inflammatory approaches. Unfortunately, results in most settings have been disappointing. The majority of novel approaches fail despite promising preclinical data, partly attributable to off-target effects. The purpose of this review, focused on inflammation following acute myocardial ischemia, is to give a brief overview of the new insights regarding research on pro-inflammatory signaling cascades that could be targeted for cardioprotective therapeutic developments.
Authors:
Anne Vincent; Benoit Lattuca; Nolwenn Merlet; Catherine Sportouch-Dukhan; Stephanie Barrère-Lemaire
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Anti-inflammatory & anti-allergy agents in medicinal chemistry     Volume:  12     ISSN:  1875-614X     ISO Abbreviation:  Antiinflamm Antiallergy Agents Med Chem     Publication Date:  2013  
Date Detail:
Created Date:  2013-02-27     Completed Date:  2013-08-13     Revised Date:  2014-09-03    
Medline Journal Info:
Nlm Unique ID:  101462262     Medline TA:  Antiinflamm Antiallergy Agents Med Chem     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  47-54     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents / adverse effects*,  therapeutic use
Clinical Trials as Topic
Cytokines / antagonists & inhibitors*,  metabolism
Humans
Inflammation / immunology*,  pathology,  prevention & control*
Mice
Myocardial Ischemia / drug therapy,  immunology*,  pathology
Myocardial Reperfusion Injury / drug therapy,  immunology
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Cytokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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