Document Detail


New insights in research about acute ischemic myocardial injury and inflammation.
MedLine Citation:
PMID:  23286292     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Recognition that inflammation may contribute to the pathogenesis of various cardiac diseases has naturally led to the evaluation of the therapeutic potential of a range of anti-inflammatory approaches. Unfortunately, results in most settings have been disappointing. The majority of novel approaches fail despite promising preclinical data, partly attributable to off-target effects. The purpose of this review, focused on inflammation following acute myocardial ischemia, is to give a brief overview of the new insights regarding research on pro-inflammatory signaling cascades that could be targeted for cardioprotective therapeutic developments.
Authors:
Anne Vincent; Benoit Lattuca; Nolwenn Merlet; Catherine Sportouch-Dukhan; Stéphanie Barrère-Lemaire
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-31
Journal Detail:
Title:  Anti-inflammatory & anti-allergy agents in medicinal chemistry     Volume:  -     ISSN:  1875-614X     ISO Abbreviation:  Antiinflamm Antiallergy Agents Med Chem     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-1-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101462262     Medline TA:  Antiinflamm Antiallergy Agents Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier, F-34094, France. anne.vincent@igf.cnrs.fr.
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