| New insights in cough. | |
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MedLine Citation:
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PMID: 21030396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic cough is common, blights patients' lives and is hard to treat. Chronic cough patients demonstrate high objective cough rates and as a group have increased cough reflex sensitivity. However, conventional cough challenge techniques show substantial overlap with normal subjects. This suggests that other important mechanisms have yet to be determined. For the last two decades, chronic cough has been considered to be caused by gastro-oesophageal reflux, post-nasal drip or asthma. However, many patients with these conditions do not have cough, and in those with cough, the response to specific treatments is unpredictable at best. In addition, many chronic cough patients do not have an identifiable cause. This raises questions about the concept of a triad of treatable causes for chronic cough. Our current understanding of the neurophysiology of the cough reflex is largely derived from animal work with limited data in humans. By analogy with chronic pain syndromes, both peripheral and central sensitization may be important mechanisms in chronic cough, and are under active investigation. We need to understand the mechanisms underlying sensitization, how they interact with cough triggers and their relationship with the sensations that drive the urge to cough, and the subsequent motor cough response in chronic cough. Only then will we develop effective interventions. |
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Authors:
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Ashley Woodcock; Emma C Young; Jacky A Smith |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-10-27 |
Journal Detail:
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Title: British medical bulletin Volume: 96 ISSN: 1471-8391 ISO Abbreviation: Br. Med. Bull. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-11-29 Completed Date: 2011-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376542 Medline TA: Br Med Bull Country: England |
Other Details:
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Languages: eng Pagination: 61-73 Citation Subset: IM |
Affiliation:
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University Hospital of South Manchester, Southmoor Road, Manchester, UK. ashley.woodcock@manchester.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antitussive Agents
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therapeutic use Asthma / complications Chronic Disease Cough / drug therapy, etiology*, physiopathology Gastroesophageal Reflux / complications Humans Vagus Nerve / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Antitussive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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