| New insights on fetal ductal constriction: role of maternal ingestion of polyphenol-rich foods. | |
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MedLine Citation:
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PMID: 20136615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fetal ductus arteriosus constriction is a clinical disorder that occurs as a result of inhibition of the prostaglandin synthesis pathway, and has long been associated to maternal intake of nonsteroidal antiinflammatory drugs in late pregnancy. As a consequence of an increased right ventricular pressure, with tricuspid regurgitation and heart failure, there is a risk for the development of neonatal pulmonary artery hypertension. This article reviews the basic knowledge of the mechanisms involved in this important disorder. Clinical and experimental evidence that maternal consumption of polyphenol-rich substances, such as herbal teas, orange and grape juice, chocolate, and others, may interfere with fetal ductus arteriosus dynamics are discussed. Preventive measures to avoid fetal ductal constriction in the third trimester of pregnancy are discussed, including the possible need to change maternal dietary orientation, aiming to limit ingestion of foods with high concentrations of polyphenol-rich substances. |
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Authors:
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Paulo Zielinsky; Antonio Luiz Piccoli; Jo?o Luiz Langer Manica; Luiz Henrique Soares Nicoloso |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert review of cardiovascular therapy Volume: 8 ISSN: 1744-8344 ISO Abbreviation: Expert Rev Cardiovasc Ther Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-08 Completed Date: 2010-05-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101182328 Medline TA: Expert Rev Cardiovasc Ther Country: England |
Other Details:
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Languages: eng Pagination: 291-8 Citation Subset: IM |
Affiliation:
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Fetal Cardiology Unit, Institute of Cardiology, Av. Princesa Isabel 395, Porto Alegre 90620-001, Brazil. zielinsky@cardiol.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents, Non-Steroidal
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adverse effects* Antioxidants / adverse effects Constriction, Pathologic / chemically induced, pathology, ultrasonography Diet / adverse effects* Ductus Arteriosus / drug effects*, embryology, pathology Echocardiography Female Fetal Diseases / chemically induced*, pathology, prevention & control, ultrasonography Flavonoids / adverse effects* Food Analysis Humans Phenols / adverse effects* Pregnancy Pregnancy Trimester, Third Prenatal Nutritional Physiological Phenomena* Ultrasonography, Prenatal Ventricular Dysfunction, Right / etiology, pathology, ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antioxidants; 0/Flavonoids; 0/Phenols; 0/polyphenols |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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