Document Detail


New insight into the clinical pharmacokinetics of cefaclor: tissue penetration.
MedLine Citation:
PMID:  10768516     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The serum pharmacokinetic data presented are generally in agreement with those obtained by other authors with both the cefaclor IR (immediate release) and AF (advanced formulation) or MR (modified release) formulations. With the new sustained-release formulation, the time of peak (Tmax) and mean residence time (MRT) values are significantly longer than those observed with the standard cefaclor IR. For the first time the penetration of the MR formulation of cefaclor was determined both in suction blister fluid (SBF) and alveolar epithelial lining fluid (ELF). Cefaclor demonstrated a high tissue distribution, with a high penetration index (PI) into blister fluid, which is at least representative of a relatively large volume of fluid-filled spaces and in part of highly vascularized tissues. SBF and ELF concentrations were higher than blood levels starting at the 4th-6th hour after dose, with longer elimination half-lives from the extravascular compartment than from serum. Cefaclor has a favorable pharmacokinetic profile, especially the new sustained-release formulation, which maintains effective concentrations for a longer time than the IR preparation. The MR formulation improves the kinetic properties of the cefaclor molecule with a prolonged MRT which allows a daily dosage of 750 mg every 12 h.
Authors:
T Mazzei; A Novelli; S Esposito; P Periti
Related Documents :
2451976 - Tracer in cisternal cerebrospinal fluid is soon detected in choroid plexus capillaries.
6635546 - Energy dispersive x-ray analysis of inner ear fluids and tissues during the ontogeny of...
806946 - Mucocililary activity in the respiratory tract as influenced by prostaglandin e.
22341806 - Pregnancy outcomes after transvaginal myomectomy by colpotomy.
20088936 - Observational study of pregnant women with a previous spontaneous abortion before the 1...
18238906 - Integrity rate of pronuclei after cryopreservation of pronuclear-zygotes as a criteria ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of chemotherapy (Florence, Italy)     Volume:  12     ISSN:  1120-009X     ISO Abbreviation:  J Chemother     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-06-26     Completed Date:  2000-06-26     Revised Date:  2009-08-04    
Medline Journal Info:
Nlm Unique ID:  8907348     Medline TA:  J Chemother     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  53-62     Citation Subset:  IM    
Affiliation:
Department of Preclinical and Clinical Pharmacology, University of Florence; Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Blister
Cefaclor / pharmacokinetics*
Cephalosporins / pharmacokinetics*
Delayed-Action Preparations
Epithelium
Female
Half-Life
Humans
Male
Middle Aged
Pulmonary Alveoli
Tissue Distribution
Chemical
Reg. No./Substance:
0/Cephalosporins; 0/Delayed-Action Preparations; 53994-73-3/Cefaclor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The changing spectrum of Group B streptococcal (GBS) infection in infants of Saudi Arabia.
Next Document:  A multicenter randomized trial of prophylaxis with intravenous cefepime + metronidazole or ceftriaxo...