Document Detail

New hypocholesterolemic abietamide derivatives. II. Synthesis and hypocholesterolemic activity of N-phenyl-delta 8-dihydroabietamides.
MedLine Citation:
PMID:  1913997     Owner:  NLM     Status:  MEDLINE    
A series of N-phenyl-delta 8-dihydroabietamide analogs were prepared and tested for hypocholesterolemic activity. The effects of substituents of the phenyl moiety on the activities were quantitatively analyzed by using various substituent parameters. The activities were enhanced by the electron-donating effect of ortho and para substitutents and the bulkiness of ortho substituents. A combination of 2,6-dimethylaniline with resin acids other than delta 8-dihydroabietic acid produced lower activities than N-(2,6-dimethylphenyl)-delta 8-dihydroabietamide, abietane-type carboxamides being somewhat stronger than pimarane-type carboxamides. The conversion of the carboxamide group to other groups resulted in more or less of a decrease in activity, giving evidence that the carboxamide group is important to hypocholesterolemic activity.
Y Fujita; Y Yoshikuni; T Sotomatsu; T Mori; T Ozaki; K Sempuku; A Ogino; M Kise; H Enomoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  39     ISSN:  0009-2363     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-11-04     Completed Date:  1991-11-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1193-8     Citation Subset:  IM    
Research Laboratories, Nippon Shinyaku Co., Ltd., Kyoto, Japan.
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MeSH Terms
Amides / chemical synthesis,  pharmacology
Anticholesteremic Agents / chemical synthesis*
Diterpenes / chemical synthesis*,  pharmacology
Rats, Inbred Strains
Structure-Activity Relationship
Reg. No./Substance:
0/Amides; 0/Anticholesteremic Agents; 0/Diterpenes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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