Document Detail


New hypocholesterolemic abietamide derivatives. II. Synthesis and hypocholesterolemic activity of N-phenyl-delta 8-dihydroabietamides.
MedLine Citation:
PMID:  1913997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of N-phenyl-delta 8-dihydroabietamide analogs were prepared and tested for hypocholesterolemic activity. The effects of substituents of the phenyl moiety on the activities were quantitatively analyzed by using various substituent parameters. The activities were enhanced by the electron-donating effect of ortho and para substitutents and the bulkiness of ortho substituents. A combination of 2,6-dimethylaniline with resin acids other than delta 8-dihydroabietic acid produced lower activities than N-(2,6-dimethylphenyl)-delta 8-dihydroabietamide, abietane-type carboxamides being somewhat stronger than pimarane-type carboxamides. The conversion of the carboxamide group to other groups resulted in more or less of a decrease in activity, giving evidence that the carboxamide group is important to hypocholesterolemic activity.
Authors:
Y Fujita; Y Yoshikuni; T Sotomatsu; T Mori; T Ozaki; K Sempuku; A Ogino; M Kise; H Enomoto
Related Documents :
7062937 - Some phytomonas and herpetomonas species form unique iso-branched polyunsaturated fatty...
10805767 - Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible f...
1247237 - Exacerbation of porphyria during treatment of pulmonary tuberculosis.
18598047 - Comparison of sugar, acids, and volatile composition in raspberry bushy dwarf virus-res...
18608757 - Synthesis and preliminary evaluation of new ursolic and oleanolic acids derivatives as ...
8908987 - Adipocere--problems in estimating the length of time since death.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  39     ISSN:  0009-2363     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-11-04     Completed Date:  1991-11-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1193-8     Citation Subset:  IM    
Affiliation:
Research Laboratories, Nippon Shinyaku Co., Ltd., Kyoto, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amides / chemical synthesis,  pharmacology
Animals
Anticholesteremic Agents / chemical synthesis*
Diterpenes / chemical synthesis*,  pharmacology
Male
Rats
Rats, Inbred Strains
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Amides; 0/Anticholesteremic Agents; 0/Diterpenes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Structures of two new fibrinolytic saponins from the seed of Luffa cylindrica Roem.
Next Document:  Studies on Balanites aegyptiaca fruits, an antidiabetic Egyptian folk medicine.