| New horny layer marker proteins for evaluating skin condition in atopic dermatitis. | |
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MedLine Citation:
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PMID: 19339807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Atopic dermatitis (AD) has a complicated pathogenesis and its clinical features vary greatly among patients. Although many clinical parameters have been reported, it remains difficult to evaluate AD skin conditions adequately. OBJECTIVE: To support better evaluation of AD patients, we attempted to develop a new, objective and noninvasive method that assesses skin condition in AD using biochemical markers in the skin's horny layer (HL). Methods: Thirty-six patients with AD, 8 with psoriasis and 16 healthy volunteers were recruited. HL samples were obtained by tape stripping from involved and uninvolved skin of the forearms. Expression levels of 6 proteins in the HL [fatty acid-binding protein-5 (FABP-5), squamous cell carcinoma antigens 2 (SCCA2), alpha-enolase, annexin II, apolipoprotein A-I and albumin] were analyzed by immunoblotting and compared with clinical data. RESULTS: The 6 proteins were detected at a high level in AD skin lesions, but scarcely in the normal controls. FABP-5 showed correlation with the local severity of the involved skin. Annexin II, apoprotein A-I and albumin showed correlation with the severity of specific eruptions. SCCA2 correlated significantly with total serum IgE level. Albumin levels in the uninvolved skin of AD patients showed significant correlation with the local severity in the involved skin of the same patient and with the trans-epidermal water loss. Albumin levels in psoriatic skin were very low, even with scratch marks, compared to those in AD skin. CONCLUSION: FABP-5, albumin and some other proteins in HL seem to be useful as biomarkers to evaluate inflammation and skin barrier conditions in AD patients. |
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Authors:
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Yumiko Yamane; Kayano Moriyama; Chie Yasuda; Satoshi Miyata; Michiko Aihara; Zenro Ikezawa; Kaoru Miyazaki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-04-02 |
Journal Detail:
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Title: International archives of allergy and immunology Volume: 150 ISSN: 1423-0097 ISO Abbreviation: Int. Arch. Allergy Immunol. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-08-17 Completed Date: 2009-09-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9211652 Medline TA: Int Arch Allergy Immunol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 89-101 Citation Subset: IM |
Copyright Information:
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Copyright 2009 S. Karger AG, Basel. |
Affiliation:
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Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Albumins / biosynthesis Annexin A2 / biosynthesis Antigens, Neoplasm / biosynthesis Apolipoprotein A-I / biosynthesis Biological Markers / analysis* Blotting, Western Child Child, Preschool Dermatitis, Atopic / metabolism*, pathology* Fatty Acid-Binding Proteins / biosynthesis Female Gene Expression* Humans Male Middle Aged Phosphopyruvate Hydratase / biosynthesis Serpins / biosynthesis Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Annexin A2; 0/Antigens, Neoplasm; 0/Apolipoprotein A-I; 0/Biological Markers; 0/FABP5 protein, human; 0/Fatty Acid-Binding Proteins; 0/Serpins; 0/squamous cell carcinoma-related antigen; EC 4.2.1.11/Phosphopyruvate Hydratase |
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