Document Detail

New horizons in the analysis of circulating cell-derived microparticles.
MedLine Citation:
PMID:  15647627     Owner:  NLM     Status:  MEDLINE    
Analysis of circulating cell-derived microparticles (MP) is becoming more refined and clinically useful. This review, stemming from lectures given at Tokyo late 2003, does not repeat prior reviews but focuses on new horizons. A major theme is the rising recognition of platelets and their MP (PMP) as key mediators of inflammation/immunity. Among the major concepts developed are that (i) many so-called soluble markers of inflammation are in reality MP-bound; (ii) PMP and other MP appear to serve important signaling and immune functions including antigen presentation. In conclusion, MP analysis is poised to enter the mainstream of clinical testing, measuring specific antigens rather than gross levels. However, more research is needed to decisively establish their functions, and international standards are needed to allow comparing results from different laboratories.
Lawrence L Horstman; Wenche Jy; Joaquin J Jimenez; Carlos Bidot; Yeon S Ahn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Keio journal of medicine     Volume:  53     ISSN:  0022-9717     ISO Abbreviation:  Keio J Med     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-01-13     Completed Date:  2005-02-18     Revised Date:  2008-08-07    
Medline Journal Info:
Nlm Unique ID:  0376354     Medline TA:  Keio J Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  210-30     Citation Subset:  IM    
The Wallace H Coulter Platelet Laboratory, University of Miami Medical Center, FL 33136, USA.
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MeSH Terms
Biological Markers / blood*
Blood Platelets / immunology*
Endothelial Cells / immunology*
Particle Size
Thrombosis / immunology*
Reg. No./Substance:
0/Biological Markers

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