Document Detail


New horizons in the analysis of circulating cell-derived microparticles.
MedLine Citation:
PMID:  15647627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Analysis of circulating cell-derived microparticles (MP) is becoming more refined and clinically useful. This review, stemming from lectures given at Tokyo late 2003, does not repeat prior reviews but focuses on new horizons. A major theme is the rising recognition of platelets and their MP (PMP) as key mediators of inflammation/immunity. Among the major concepts developed are that (i) many so-called soluble markers of inflammation are in reality MP-bound; (ii) PMP and other MP appear to serve important signaling and immune functions including antigen presentation. In conclusion, MP analysis is poised to enter the mainstream of clinical testing, measuring specific antigens rather than gross levels. However, more research is needed to decisively establish their functions, and international standards are needed to allow comparing results from different laboratories.
Authors:
Lawrence L Horstman; Wenche Jy; Joaquin J Jimenez; Carlos Bidot; Yeon S Ahn
Related Documents :
21908357 - An applied printing immunoassay with recombinant nc-sag1 for detection of antibodies to...
20143947 - Defining the humoral immune response to infectious agents using high-density protein mi...
20065647 - Characterization of a chimeric monoclonal antibody against the insulin-like growth fact...
3077057 - Molecular biotherapy with human monoclonal antibodies.
10948127 - Fecal antibodies to cryptosporidium parvum in healthy volunteers.
18508407 - Distribution of filarial elephantiasis and hydrocele in matara district, sri lanka, as ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Keio journal of medicine     Volume:  53     ISSN:  0022-9717     ISO Abbreviation:  Keio J Med     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-01-13     Completed Date:  2005-02-18     Revised Date:  2008-08-07    
Medline Journal Info:
Nlm Unique ID:  0376354     Medline TA:  Keio J Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  210-30     Citation Subset:  IM    
Affiliation:
The Wallace H Coulter Platelet Laboratory, University of Miami Medical Center, FL 33136, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood*
Blood Platelets / immunology*
Endothelial Cells / immunology*
Humans
Particle Size
Thrombosis / immunology*
Chemical
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Residency training in emergency medicine: the challenges of the 21st century.
Next Document:  Brain plasticity in health and disease.