| New horizons at the caudal embryos: coordinated urogenital/reproductive organ formation by growth factor signaling. | |
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MedLine Citation:
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PMID: 19765973 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cloaca/urogenital sinus and its adjacent region differentiate into the urogenital/reproductive organs. Caudal regression syndrome (CRS; including mermaid syndrome), a type of severe cloacal malformation displays hindlimb fusion and urogenital organ defects, thus suggesting that such defects are caused by several morphogenetic alterations during early development. The attenuation of bone morphogenetic protein (Bmp) signaling at the posterior primitive streak of embryos leads to the caudal dysmorphogenesis including the cloaca and fusion of both hindlimbs. Genetic tissue lineage studies indicate the presence of coordinated organogenesis. Hedgehog (HH)-responding cells derived from peri-cloacal mesenchyme (PCM) contribute to the urogenital/reproductive organs. These findings indicate the existence of developmental programs for the coordinated organogenesis of urogenital/reproductive tissues based on growth factor function and crosstalk. |
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Authors:
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Kentaro Suzuki; Aris Economides; Motoko Yanagita; Daniel Graf; Gen Yamada |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2009-09-16 |
Journal Detail:
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Title: Current opinion in genetics & development Volume: 19 ISSN: 1879-0380 ISO Abbreviation: Curr. Opin. Genet. Dev. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-11-05 Completed Date: 2010-01-06 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9111375 Medline TA: Curr Opin Genet Dev Country: England |
Other Details:
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Languages: eng Pagination: 491-6 Citation Subset: IM |
Affiliation:
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Division of Organ Formation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Embryo, Mammalian / abnormalities, embryology* Genitalia / embryology* Hedgehog Proteins / genetics, physiology Humans Intercellular Signaling Peptides and Proteins / genetics, physiology* Models, Biological Organogenesis / genetics Signal Transduction / genetics, physiology Time Factors Urogenital System / embryology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 ES016597-01A1/ES/NIEHS NIH HHS; R01-ES016597-01A1/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hedgehog Proteins; 0/Intercellular Signaling Peptides and Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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