| New hemodynamic approach to angiogenesis: color and pulsed Doppler ultrasonography. | |
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MedLine Citation:
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PMID: 10084663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE AND OBJECTIVES: To determine the capacity of color and spectral Doppler ultrasonography (US) to quantify angiogenesis in vivo and to characterize low-resistance intratumor blood flow. METHODS: Thirty-two tumors, xenografted into mice, were studied with Doppler US. The number of intratumor vessels visualized with color Doppler US was compared with the density of microvessels and the number of vessels >100 microm determined by histologic examination. The resistance index and the peak systolic velocities were evaluated. RESULTS: The number of intratumor vessels visualized by color Doppler US was correlated with the number of vessels >100 microm (P<0.001) determined histologically. When vessel density was >30, intratumor vessels were always detected by color Dopper US. The resistance index and peak systolic velocities were significantly lower in intratumor than in peritumor vessels. CONCLUSIONS: Color Doppler US evaluated tumor angiogenesis accurately. Spectral analysis confirmed the low resistance of intratumor blood flow. |
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Authors:
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N Lassau; C Paturel-Asselin; J M Guinebretiere; J Leclère; S Koscielny; A Roche; S Chouaib; P Peronneau |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Investigative radiology Volume: 34 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-07-08 Completed Date: 1999-07-08 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 194-8 Citation Subset: IM |
Affiliation:
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Department of Medical Imaging, Institut Gustave Roussy, Villejuif, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Capillary Resistance Immunohistochemistry Melanoma / blood supply*, ultrasonography* Mice Mice, Nude Neovascularization, Pathologic / ultrasonography* Statistics, Nonparametric Ultrasonography, Doppler, Color Ultrasonography, Doppler, Pulsed |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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