| New haliangicin isomers, potent antifungal metabolites produced by a marine myxobacterium. | |
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MedLine Citation:
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PMID: 14513906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Haliangicin is a beta-methoxyacrylate-type polyene antibiotic isolated from the unique marine myxobacterium Haliangium ochraceum. A further investigation of the extract of this microorganism has resulted in the isolation of haliangicin as well as its geometrical isomers. The configuration of the epoxide in haliangicin, which was unknown previously, was determined in this study. The planar structures with partial stereochemistry of these isomers were elucidated by spectroscopic analyses. The major isomer, cis-haliangicin, is a cis isomer of the epoxide portion of haliangicin. Haliangicins B approximately D are geometrical isomers of the polyene moiety, and present as an inseparable mixture of cis and trans epoxide isomers. Their antifungal activities were also evaluated in comparison with haliangicin. |
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Authors:
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Bangi A Kundim; Yu Itou; Youji Sakagami; Ryosuke Fudou; Takashi Iizuka; Shigeru Yamanaka; Makoto Ojika |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of antibiotics Volume: 56 ISSN: 0021-8820 ISO Abbreviation: J. Antibiot. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-09-29 Completed Date: 2003-10-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0151115 Medline TA: J Antibiot (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 630-8 Citation Subset: IM |
Affiliation:
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Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antifungal Agents
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chemistry*,
isolation & purification,
pharmacology Chromatography, Gel Fatty Acids, Unsaturated / biosynthesis, chemistry*, isolation & purification, pharmacology Gram-Negative Bacteria / metabolism* Nuclear Magnetic Resonance, Biomolecular Oleic Acids / chemistry, isolation & purification, pharmacology Phytophthora / growth & development, metabolism Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Stereoisomerism Water Microbiology |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Fatty Acids, Unsaturated; 0/Oleic Acids; 0/haliangicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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