Document Detail

New-generation anticoagulants: the low molecular weight heparins.
MedLine Citation:
PMID:  10577408     Owner:  NLM     Status:  MEDLINE    
Heparin has been the mainstay of acute anticoagulation therapy for decades. Within the past 20 years, several different heparin fractions-collectively known as low molecular weight heparins (LMWHs)-have been evaluated in various medical and surgical settings in which anticoagulation is routinely warranted. The LMWHs are efficacious, safe, cost-effective, and easier to administer and monitor than standard, unfractionated heparin. As LMWH use becomes more widespread, emergency physicians will use these new agents instead of unfractionated heparin for unstable angina, non-Q-wave myocardial infarction, or thromboembolic disease. This review focuses on the pharmacologic properties of unfractionated heparin and LMWH, associated complications, and the use of these agents in acute ischemic coronary syndromes, thromboembolic disease, and other selected clinical situations.
H C Hovanessian
Related Documents :
21984538 - The coronary circulation in exercise training.
9236418 - Comparison of low-molecular-weight heparin with unfractionated heparin acutely and with...
10662478 - Cost-effectiveness analysis of enoxaparin versus unfractionated heparin for acute coron...
10983738 - Clopidogrel: a review of its use in the prevention of atherothrombosis.
18349088 - Relationship of paraoxonase 1 (pon1) gene polymorphisms and functional activity with sy...
12103258 - Evaluation of the time saved by prehospital initiation of reteplase for st-elevation my...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of emergency medicine     Volume:  34     ISSN:  0196-0644     ISO Abbreviation:  Ann Emerg Med     Publication Date:  1999 Dec 
Date Detail:
Created Date:  1999-12-29     Completed Date:  1999-12-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8002646     Medline TA:  Ann Emerg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  768-79     Citation Subset:  AIM; IM    
Department of Emergency Medicine, University of California-San Francisco, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Angina, Unstable / drug therapy
Anticoagulants / pharmacokinetics,  pharmacology*,  therapeutic use*
Heparin, Low-Molecular-Weight / pharmacokinetics,  pharmacology*,  therapeutic use*
Myocardial Infarction / drug therapy
Pulmonary Embolism / drug therapy
Venous Thrombosis / drug therapy
Reg. No./Substance:
0/Anticoagulants; 0/Heparin, Low-Molecular-Weight
Comment In:
Ann Emerg Med. 2000 Sep;36(3):277-8   [PMID:  10969239 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Twenty-four-hour access to emergency care for children in managed care.
Next Document:  The Costa Rican emergency medicine residency: design and implementation of a new specialty training ...