Document Detail


New-generation anticoagulants: the low molecular weight heparins.
MedLine Citation:
PMID:  10577408     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heparin has been the mainstay of acute anticoagulation therapy for decades. Within the past 20 years, several different heparin fractions-collectively known as low molecular weight heparins (LMWHs)-have been evaluated in various medical and surgical settings in which anticoagulation is routinely warranted. The LMWHs are efficacious, safe, cost-effective, and easier to administer and monitor than standard, unfractionated heparin. As LMWH use becomes more widespread, emergency physicians will use these new agents instead of unfractionated heparin for unstable angina, non-Q-wave myocardial infarction, or thromboembolic disease. This review focuses on the pharmacologic properties of unfractionated heparin and LMWH, associated complications, and the use of these agents in acute ischemic coronary syndromes, thromboembolic disease, and other selected clinical situations.
Authors:
H C Hovanessian
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of emergency medicine     Volume:  34     ISSN:  0196-0644     ISO Abbreviation:  Ann Emerg Med     Publication Date:  1999 Dec 
Date Detail:
Created Date:  1999-12-29     Completed Date:  1999-12-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8002646     Medline TA:  Ann Emerg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  768-79     Citation Subset:  AIM; IM    
Affiliation:
Department of Emergency Medicine, University of California-San Francisco, USA. hoori@gte.net
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MeSH Terms
Descriptor/Qualifier:
Angina, Unstable / drug therapy
Anticoagulants / pharmacokinetics,  pharmacology*,  therapeutic use*
Heparin, Low-Molecular-Weight / pharmacokinetics,  pharmacology*,  therapeutic use*
Humans
Myocardial Infarction / drug therapy
Pulmonary Embolism / drug therapy
Venous Thrombosis / drug therapy
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Heparin, Low-Molecular-Weight
Comments/Corrections
Comment In:
Ann Emerg Med. 2000 Sep;36(3):277-8   [PMID:  10969239 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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