Document Detail

New gender-specific partition values for ECG criteria of left ventricular hypertrophy: recalibration against cardiac MRI.
MedLine Citation:
PMID:  15226274     Owner:  NLM     Status:  MEDLINE    
ECG criteria for left ventricular hypertrophy (LVH) were mostly validated using left ventricular mass (LVM) as measured by M-mode echocardiography. LVM as measured by cardiac MRI has been demonstrated to be much more accurate and reproducible. We reevaluated the sensitivity and specificity of 4 ECG criteria of LVH against LVM as measured by cardiac MRI. Patients with systemic hypertension (n=288) and 60 normal volunteers had their LVM measured using a 1.5-Tesla MRI system. A 12-lead ECG was recorded, and 4 ECG criteria were evaluated: Sokolow-Lyon voltage, Cornell voltage, Cornell product, and Sokolow-Lyon product. Based on a cardiac MRI normal range, 39.9% of the hypertensive males and 36.7% of the hypertensive females had elevated LVM index. At a specificity of 95%, the Sokolow-Lyon product criterion had the highest sensitivity in females (26.2%), the Cornell criterion had the highest sensitivity in males (26.2%), and the Cornell product criteria had a relatively high sensitivity in both males and females (25.0% and 23.8%). Receiver operating characteristic curves showed the Cornell and Cornell product criteria to be superior for males whereas the Sokolow-Lyon product criterion was superior for females. Comparing the mean LVM index values of the subjects who were ECG LVH positive to the normal volunteers indicated that the ECG LVH criteria detect individuals with an LVM index substantially above the normal range. We have redefined the partition values for 4 different ECG LVH criteria, according to gender, and found that they detect subjects with markedly elevated LVM index.
Khaled Alfakih; Kevin Walters; Tim Jones; John Ridgway; Alistair S Hall; Mohan Sivananthan
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies     Date:  2004-06-28
Journal Detail:
Title:  Hypertension     Volume:  44     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-30     Completed Date:  2004-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  175-9     Citation Subset:  IM    
British Heart Foundation Cardiac MRI Unit, Leeds General Infirmary, Leeds, UK.
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MeSH Terms
Analysis of Variance
Electrocardiography / standards*
Hypertension / complications,  diagnosis
Hypertrophy, Left Ventricular / complications,  diagnosis*
Magnetic Resonance Imaging*
Middle Aged
ROC Curve
Sensitivity and Specificity
Sex Characteristics
Comment In:
Hypertension. 2004 Dec;44(6):e13   [PMID:  15534079 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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