Document Detail


New frontiers in transfusion biology: identification and significance of mediators of morbidity and mortality in stored red blood cells.
MedLine Citation:
PMID:  21496049     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Red blood cell (RBC) transfusions are associated with inflammation and thrombosis, both arterial and venous, the mechanisms of which are not understood. Although a necessary life-saving procedure in modern medicine, transfusions have rarely been subjected to modern assessments of efficacy and safety, including randomized trials. Storage of RBCs induces changes, including the release of free hemoglobin and the accumulation of biologically active soluble mediators and microparticles. These mediators likely play a direct role in the inflammatory and prothrombotic properties of RBC transfusions. Methods such as leukoreduction, washing of RBCs, and rejuvenation may improve the quality of RBC transfusions.
Authors:
Katie Grimshaw; Julie Sahler; Sherry L Spinelli; Richard P Phipps; Neil Blumberg
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Transfusion     Volume:  51     ISSN:  1537-2995     ISO Abbreviation:  Transfusion     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-18     Completed Date:  2011-06-13     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  United States    
Other Details:
Languages:  eng     Pagination:  874-80     Citation Subset:  IM    
Copyright Information:
© 2011 American Association of Blood Banks.
Affiliation:
Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
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MeSH Terms
Descriptor/Qualifier:
Blood Platelets / cytology,  metabolism
Blood Preservation / adverse effects*
Erythrocyte Transfusion / adverse effects*,  methods*
Erythrocytes / cytology,  metabolism
Humans
Grant Support
ID/Acronym/Agency:
ES01247/ES/NIEHS NIH HHS; HL078603/HL/NHLBI NIH HHS; HL095467/HL/NHLBI NIH HHS; HL100051/HL/NHLBI NIH HHS; R01 HL095467/HL/NHLBI NIH HHS; R01 HL095467-01A1/HL/NHLBI NIH HHS; R01 HL095467-02/HL/NHLBI NIH HHS; R01 HL095467-03/HL/NHLBI NIH HHS; R01 HL095467-04/HL/NHLBI NIH HHS
Comments/Corrections

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