| New frontiers in headache therapy. | |
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MedLine Citation:
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PMID: 21533724 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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There are numerous headache therapies available for our patients, more for migraine than for any of the other primary headache disorders. Only four medications have been approved for migraine prevention in the last few decades in the US and onabotulinumtoxinA was recently approved in the UK and the US for chronic migraine. We have been more fortunate in the acute care arena where in the US we have had seven triptans and one nonsteroidal anti-inflammatory medication approved by the FDA and currently available. There are several other acute care medications in various stages of development and there are two new methods of administering a triptan and others under investigation. We are always looking for faster, easier and more efficient administration of medications with fewer adverse events, as optimal migraine therapy requires these characteristics. What follows is a brief review of the progress in development for four of the many new acute care medications being investigated: the CGRP antagonist tablet telcagepant, the sumatriptan iontophoretic patch, sumatriptan powder for use in the OptiNose apparatus and the dihydroergotamine oral inhaler. I will not include transcranial magnetic stimulation, a 5-HT(1F) agonist, large conductance calcium-activated potassium channel openers, glial modulators or other medications and devices in early stages of development [1]. |
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Authors:
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A Rapoport |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology Volume: 32 Suppl 1 ISSN: 1590-3478 ISO Abbreviation: Neurol. Sci. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100959175 Medline TA: Neurol Sci Country: Italy |
Other Details:
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Languages: eng Pagination: 105-9 Citation Subset: IM |
Affiliation:
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David Geffen School of Medicine at UCLA, 239 South Orange Drive, Los Angeles, CA, 90036, USA, alanrapoport@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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