Document Detail

New frontiers in cardiovascular behavioral medicine: comparative effectiveness of exercise and medication in treating depression.
MedLine Citation:
PMID:  21972328     Owner:  NLM     Status:  MEDLINE    
Exercise, considered a mainstay of cardiac rehabilitation, has been shown to reduce cardiac risk factors such as hyperlipidemia and hypertension. Growing evidence also suggests that exercise has beneficial effects on mental health, which is relevant for cardiac patients because of the prognostic significance of depression in patients with coronary heart disease (CHD). Depression has been associated with increased mortality and nonfatal cardiac events in patients with CHD; it is also associated with worse outcomes in patients who undergo coronary artery bypass graft surgery and those who have heart failure. The standard therapy for depression is pharmacologic treatment, often with second-generation antidepressants such as selective serotonin reuptake inhibitors. Despite their widespread use, antidepressants have only modest effects on depression for many patients compared with placebo controls. Exercise therapy, already an established component of cardiac rehabilitation, has potential efficacy as a treatment for depression in cardiac disease patients. Randomized controlled trials are needed to determine the clinical effects of exercise in this population and to compare the effects of exercise with those of antidepressants.
James A Blumenthal
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Cleveland Clinic journal of medicine     Volume:  78 Suppl 1     ISSN:  1939-2869     ISO Abbreviation:  Cleve Clin J Med     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-10-05     Completed Date:  2012-12-17     Revised Date:  2013-08-27    
Medline Journal Info:
Nlm Unique ID:  8703441     Medline TA:  Cleve Clin J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S35-43     Citation Subset:  IM    
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA.
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MeSH Terms
Antidepressive Agents / therapeutic use*
Behavioral Medicine / trends*
Cardiovascular Diseases / drug therapy,  psychology,  rehabilitation*
Depression / psychology,  therapy*
Exercise Therapy*
Heart Failure
Risk Factors
Treatment Outcome
Grant Support
Reg. No./Substance:
0/Antidepressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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