| New findings in pulmonary arteries of rats with hypoxia-induced pulmonary hypertension. | |
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MedLine Citation:
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PMID: 136978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats have been kept in a hypobaric chamber, and thus hypoxic, for up to 28 days in order to study the structural changes in the pulmonary arteries during the development of pulmonary hypertension. Rats were studied after 3, 5, 7, 10, 14, 21 and 28 days at a pressure of 380 mmHg. Right ventricular hypertrophy was demonstrated after 5 days in the hypoxic environment but increased up to 10 days. After pulmonary arterial injection microscopic counts of small arteries showed that vessels up to 200 mum external diameter were gradually "lost", reducing the ratio of arterial to alveolar number significantly by 14 days. No vestiges of these vessels were found with light microscopy. At the same time a gradual increase in arterial wall thickness was demonstrated and also progressive extension of muscle into smaller and more peripheral vessels than normal. In both these features maximum increase was reached by 14 days of exposure though changes were apparent after only 3. Similar changes have been found in patients with cystic fibrosis and chronic bronchitis using the same measuring techniques. |
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Authors:
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A Hislop; L Reid |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of experimental pathology Volume: 57 ISSN: 0007-1021 ISO Abbreviation: Br J Exp Pathol Publication Date: 1976 Oct |
Date Detail:
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Created Date: 1977-02-24 Completed Date: 1977-02-24 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 0372543 Medline TA: Br J Exp Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 542-54 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / complications* Body Weight Cardiomegaly / etiology Hypertension, Pulmonary / complications, etiology, pathology* Male Myocardium / pathology Organ Size Pulmonary Alveoli / pathology Pulmonary Artery / pathology* Rats Time Factors |
| Comments/Corrections | |
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