Document Detail


New families of bioactive oxidized phospholipids generated by immune cells: identification and signaling actions.
MedLine Citation:
PMID:  22802337     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Phospholipids are of critical importance in mammalian cell biology, both through providing a permeability barrier and acting as substrates for synthesis of lipid mediators. Recently, several new families of bioactive lipids were identified that form through the enzymatic oxidation of membrane phospholipids in circulating innate immune cells and platelets. These comprise eicosanoids attached to phosphatidylethanolamine and phosphatidylcholine and form within 2-5 minutes of cell activation by pathophysiologic agonists, via the coordinated action of receptors and enzymes. In this review, we summarize what is currently known regarding their structures, mechanisms of formation, cell biology, and signaling actions. We show that phospholipid oxidation by acutely activated immune cells is a controlled event, and we propose a central role in regulating membrane biology and innate immune function during health and disease. We also review the mass spectrometry methods used for identification of the lipids and describe how these approaches can be used for discovery of new lipid mediators in complex biologic samples.
Authors:
Valerie B O'Donnell; Robert C Murphy
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-07-16
Journal Detail:
Title:  Blood     Volume:  120     ISSN:  1528-0020     ISO Abbreviation:  Blood     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-07     Completed Date:  2012-11-27     Revised Date:  2013-09-10    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1985-92     Citation Subset:  AIM; IM    
Affiliation:
Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Platelets / immunology,  metabolism
Cell Communication
Eicosanoids / chemistry*,  immunology,  metabolism
Humans
Immunity, Innate
Macrophages / immunology,  metabolism*
Mass Spectrometry
Mice
Monocytes / immunology,  metabolism*
Oxidation-Reduction
Phosphatidylcholines / chemistry*,  immunology,  metabolism
Phosphatidylethanolamines / chemistry*,  immunology,  metabolism
Signal Transduction
Chemical
Reg. No./Substance:
0/Eicosanoids; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 39382-08-6/phosphatidylethanolamine
Comments/Corrections

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