| New families of bioactive oxidized phospholipids generated by immune cells: identification and signaling actions. | |
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MedLine Citation:
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PMID: 22802337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phospholipids are of critical importance in mammalian cell biology, both through providing a permeability barrier and acting as substrates for synthesis of lipid mediators. Recently, several new families of bioactive lipids were identified that form through the enzymatic oxidation of membrane phospholipids in circulating innate immune cells and platelets. These comprise eicosanoids attached to phosphatidylethanolamine and phosphatidylcholine and form within 2-5 minutes of cell activation by pathophysiologic agonists, via the coordinated action of receptors and enzymes. In this review, we summarize what is currently known regarding their structures, mechanisms of formation, cell biology, and signaling actions. We show that phospholipid oxidation by acutely activated immune cells is a controlled event, and we propose a central role in regulating membrane biology and innate immune function during health and disease. We also review the mass spectrometry methods used for identification of the lipids and describe how these approaches can be used for discovery of new lipid mediators in complex biologic samples. |
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Authors:
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Valerie B O'Donnell; Robert C Murphy |
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Publication Detail:
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Type: Journal Article; Review Date: 2012-07-16 |
Journal Detail:
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Title: Blood Volume: 120 ISSN: 1528-0020 ISO Abbreviation: Blood Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-09-07 Completed Date: 2012-11-27 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
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Languages: eng Pagination: 1985-92 Citation Subset: AIM; IM |
Affiliation:
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Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Platelets / immunology, metabolism Cell Communication Eicosanoids / chemistry*, immunology, metabolism Humans Immunity, Innate Macrophages / immunology, metabolism* Mass Spectrometry Mice Monocytes / immunology, metabolism* Oxidation-Reduction Phosphatidylcholines / chemistry*, immunology, metabolism Phosphatidylethanolamines / chemistry*, immunology, metabolism Signal Transduction |
| Chemical | |
Reg. No./Substance:
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0/Eicosanoids; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 39382-08-6/phosphatidylethanolamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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