| New evidence for involvement of the entorhinal region in schizophrenia: a combined MRI volumetric and DTI study. | |
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MedLine Citation:
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PMID: 15670689 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Postmortem examinations and magnetic resonance imaging (MRI) studies suggest involvement of the entorhinal cortex (EC) in schizophrenic psychoses. However, the extent and nature of the possible pathogenetical process underlying the observed alterations of this limbic key region for processing of multimodal sensory information remains unclear. Three-dimensional high-resolution MRI volumetry and evaluation of the regional diffusional anisotropy based on diffusion tensor imaging (DTI) were performed on the EC of 15 paranoid schizophrenic patients and 15 closely matched control subjects. In schizophrenic patients, EC volumes showed a slight, but not significant, decrease. However, the anisotropy values, expressed as inter-voxel coherences (COH), were found to be significantly decreased by 17.9% (right side) and 12.5% (left side), respectively, in schizophrenics. Reduction of entorhinal diffusional anisotropy can be hypothesized to be functionally related to disturbances in the perforant path, the principal efferent EC fiber tract supplying the limbic system with neuronal input from multimodal association centers. Combinations of different MRI modalities are a promising approach for the detection and characterization of subtle brain tissue alterations. |
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Authors:
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Peter Kalus; Johannes Slotboom; Jürgen Gallinat; Andrea Federspiel; Jan Gralla; Luca Remonda; Werner K Strik; Gerhard Schroth; Claus Kiefer |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2004-12-09 |
Journal Detail:
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Title: NeuroImage Volume: 24 ISSN: 1053-8119 ISO Abbreviation: Neuroimage Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-01-26 Completed Date: 2005-04-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: United States |
Other Details:
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Languages: eng Pagination: 1122-9 Citation Subset: IM |
Affiliation:
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Clinic for Psychiatry and Psychotherapy, Charité University Medicine, Campus Mitte, Turmstrasse 21, D-10559 Berlin, Germany. peter.kalus@charite.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aging / physiology Anisotropy Antipsychotic Agents / therapeutic use Diffusion Magnetic Resonance Imaging Entorhinal Cortex / pathology* Female Humans Image Processing, Computer-Assisted Individuality Male Psychiatric Status Rating Scales Schizophrenia / drug therapy, pathology* Sex Characteristics |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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