| New and efficient routes to biomolecules substituted with cyclopentadienyltricarbonylrhenium and -technetium derivatives. | |
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MedLine Citation:
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PMID: 11446631 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The small, compact, robust, and nonpolar units of [CpM(CO)3] (M = Re, Tc) coupled with biomolecules may be considered as bioorganometallic entities of potential interest in the field of medicinal chemistry. However, the short half-life of useful radionuclides (186Re t1/2 = 3.7 d, 188Re t1/2 = 16.8 h, 99mTc t1/2 = 6 h), the risks inherent in their use, and their cost have led chemists to search for novel synthetic strategies that allow the rapid introduction of the [CpM(CO)3] moiety as a late step in the course of synthesizing the target molecule. The present paper describes different strategies recently reported in the literature to tackle this problem. |
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Authors:
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F Le Bideau; M Salmain; S Top; G Jaouen |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chemistry (Weinheim an der Bergstrasse, Germany) Volume: 7 ISSN: 0947-6539 ISO Abbreviation: Chemistry Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-07-11 Completed Date: 2001-07-26 Revised Date: 2009-08-04 |
Medline Journal Info:
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Nlm Unique ID: 9513783 Medline TA: Chemistry Country: Germany |
Other Details:
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Languages: eng Pagination: 2289-94 Citation Subset: IM |
Affiliation:
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UMR 7576 CNRS, Ecole Nationale Supérieure de Chimie de Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast Neoplasms
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drug therapy Chemistry, Pharmaceutical / methods Cyclopentanes / chemistry* Estrogens / chemical synthesis*, chemistry Half-Life Molecular Structure Octreotide / chemistry Organometallic Compounds / chemical synthesis*, chemistry Organotechnetium Compounds / chemical synthesis*, chemistry Peptides / chemistry Proteins / chemistry Radioisotopes / chemistry*, diagnostic use Radiopharmaceuticals / chemical synthesis*, chemistry Rhenium / chemistry*, diagnostic use Selective Estrogen Receptor Modulators / chemistry Structure-Activity Relationship Tamoxifen / analogs & derivatives, chemical synthesis*, chemistry, therapeutic use Technetium Tc 99m Sestamibi / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Cyclopentanes; 0/Estrogens; 0/Organometallic Compounds; 0/Organotechnetium Compounds; 0/Peptides; 0/Proteins; 0/Radioisotopes; 0/Radiopharmaceuticals; 0/Selective Estrogen Receptor Modulators; 10540-29-1/Tamoxifen; 109581-73-9/Technetium Tc 99m Sestamibi; 6317-25-5/fulvene; 7440-15-5/Rhenium; 83150-76-9/Octreotide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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